ArticleThe Journal of clinical investigation1987
Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone.
Article in The Journal of clinical investigation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 234 citations in OpenAlex.
- Intracellular calcium and blood pressure: comparison between primary hyperparathyroidism and essential hypertension.Journal of endocrinological investigation · 1995Trial
- Renal phosphate wasting in the absence of adenylyl cyclase 6.Journal of the American Society of Nephrology : JASN · 2014Article
- Molecular mechanisms and regulation of urinary acidification.Comprehensive Physiology · 2014Review
- Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.The Journal of biological chemistry · 2010Article
- Article
- Hormonal regulation and implication of cell signaling in calcium transfer by placenta.Endocrine · 2001Review
- Ca2+ transport by the luminal membrane of the distal nephron: action and interaction of protein kinases A and C.The Biochemical journal · 1997Article
- Age dependence of tolerance to anoxia and changes in cytosolic calcium in rabbit renal proximal tubules.Pediatric nephrology (Berlin, Germany) · 1996Article
- Patch-clamp evidence for calcium channels in apical membranes of rabbit kidney connecting tubules.The Journal of clinical investigation · 1993Article
- The role of protein phosphorylation in renal amino acid transport.Pediatric nephrology (Berlin, Germany) · 1993Review
- Effect of parathyroid hormone on acid/base transport in rabbit renal proximal tubule S3 segment.Pflugers Archiv : European journal of physiology · 1993Article
- Role of protein kinase C in parathyroid hormone stimulation of renal 1,25-dihydroxyvitamin D3 secretion.The Journal of clinical investigation · 1992Article
- Apical and basolateral Na/H exchange in cultured murine proximal tubule cells (MCT): effect of parathyroid hormone (PTH).The Journal of membrane biology · 1992Article
- The renal cytochrome P-450 arachidonic acid system.Pediatric nephrology (Berlin, Germany) · 1992Review
- Ca2+ uptake by endoplasmic reticulum of renal cortex. II. Effects of uninephrectomy and parathyroidectomy.Calcified tissue international · 1992Article
- Parathyroid hormone decreases HCO3 reabsorption in the rat proximal tubule by stimulating phosphatidylinositol metabolism and inhibiting base exit.The Journal of clinical investigation · 1992Article
- Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Polarized expression of Na+/H+ exchange activity in LLC-PK1/PKE20 cells: II. Hormonal regulation.Pflugers Archiv : European journal of physiology · 1992Article
- Parathyroid hormone enhances calcium current in snail neurones--simulation of the effect by phorbol esters.Pflugers Archiv : European journal of physiology · 1992Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Parathyroid hormone (PTH) produced a dose-dependent immediate stimulation of inositol triphosphate and diacylglycerol production in the opossum kidney cell line, primary culture proximal tubular cells, and basolateral membranes from canine proximal tubular segments. The increase in inositol triphosphate production was accompanied by a minor increase in inositol phosphate and no significant increase in inositol bisphosphate production. Associated with the changes in inositol triphosphate and diacylglycerol, there was an immediate hydrolysis of phosphatidylinositol 4'5-bisphosphate. The effect on phospholipid hydrolysis was followed by stimulation of phosphorylation of phosphatidylinositol 4' monophosphate and phosphatidylinositol. PTH produced a sudden increase in cytoplasmic Ca2+ in opossum kidney cells that persisted for approximately 1 min. Inositol triphosphate transiently increased cytoplasmic Ca2+ in saponin-treated opossum kidney and primary culture proximal tubule cells. The effects of PTH were not mimicked by cyclic nucleotides. In fact, cyclic AMP appeared to diminish inositol triphosphate production. These results demonstrate that PTH may activate renal tubular epithelial cells by the production of inositol triphosphate and diacylglycerol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.