Evidence map›Paper›PMID 30252494›Full record

ArticleAmerican journal of respiratory and critical care medicine2018

The Y Chromosome Regulates BMPR2 Expression via SRY: A Possible Reason "Why" Fewer Males Develop Pulmonary Arterial Hypertension.

Ling Yan, Joy D Cogan, Lora K Hedges, Bethany Nunley, Rizwan Hamid, Eric D Austin

Abstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Review
  8. Review
  9. A dUTY to Protect: Addressing "Y" We See Sex Differences in Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2022
    Article
  10. Y-Chromosome Gene,American journal of respiratory and critical care medicine · 2022
    Article
  11. Review
  12. Article
  13. Oxygen Sensing: Physiology and Pathophysiology.Antioxidants (Basel, Switzerland) · 2022
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ling Yan1 Vanderbilt University Medical Center Nashville, Tennessee.
Joy D Cogan1 Vanderbilt University Medical Center Nashville, Tennessee.
Lora K Hedges1 Vanderbilt University Medical Center Nashville, Tennessee.
Bethany Nunley1 Vanderbilt University Medical Center Nashville, Tennessee.
Rizwan Hamid1 Vanderbilt University Medical Center Nashville, Tennessee.
Eric D Austin1 Vanderbilt University Medical Center Nashville, Tennessee.ORCID 0000-0002-1709-9022

Funding

Sex Hormones in Pulmonary Arterial HypertensionP01HL108800 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWMAN, JOHN HUGHES · 2012 to 2021
$22.0M
Estrogen signaling and energy metabolism in pulmonary arterial hypertensionR01HL134802 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AUSTIN, ERIC DOUGLAS · 2018 to 2022
$3.7M
Role of bone marrow cells in pathogenesis and therapy of heritable pulmonary arterial hypertensionR01HL136748 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAMID, RIZWAN · 2017 to 2020
$2.5M
Role of BMPR2 expression in HPAH; implications for novel therapeutic approachesR01HL102020 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAMID, RIZWAN · 2011 to 2015
$2.3M
NHLBI NIH HHS P01 HL108800NHLBI NIH HHS R01 HL102020NHLBI NIH HHS R01 HL134802NHLBI NIH HHS R01 HL136748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone Morphogenetic Protein Receptors, Type IIChromosomes, Human, YFemaleHumansHypertension, PulmonaryMaleSex-Determining Region Y ProteinSex FactorsBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IISex-Determining Region Y Protein

Identifiers

PMID30252494
PMCPMC6298637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.