Evidence map›Paper›PMID 30252436›Full record

ArticleACS chemical neuroscience2019

Caffeine Modulates Spontaneous Adenosine and Oxygen Changes during Ischemia and Reperfusion.

Ying Wang, B Jill Venton

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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  8. AACS chemical neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ying WangDepartment of Chemistry , University of Virginia , Charlottesville , Virginia 22904 , United States.
B Jill VentonDepartment of Chemistry , University of Virginia , Charlottesville , Virginia 22904 , United States.ORCID 0000-0002-5096-9309
University of Virginia · US

Funding

Mechanism and function of transient adenosine signaling in the brainR01NS076875 · NINDS · UNIVERSITY OF VIRGINIA · PI VENTON, B. JILL · 2012 to 2016
$1.6M
Tunable Carbon Electrodes for in vivo Neurotransmitter DetectionR01EB026497 · NIBIB · UNIVERSITY OF VIRGINIA · PI VENTON, B. JILL · 2018 to 2021
$1.4M
NIBIB NIH HHS R01 EB026497NINDS NIH HHS R01 NS076875
6 · The paper itself

Abstract

Adenosine is an endogenous neuroprotectant that modulates vasodilation in the central nervous system. Oxygen changes occur when there is an increase in local cerebral blood flow and thus are a measure of vasodilation. Transient oxygen events following rapid adenosine events have been recently discovered, but the relationship between adenosine and blood flow change during ischemia/reperfusion (I/R) has not been characterized. Caffeine is a nonselective adenosine receptor antagonist that can modulate the effects of adenosine in the brain, but how it affects adenosine and oxygen levels during I/R is also unknown. In this study, extracellular changes in adenosine and oxygen were simultaneously monitored using fast-scan cyclic voltammetry during bilateral common carotid artery occlusion (BCCAO) and the effects of a specific A

Indexed as

AdenosineAdenosine A2 Receptor AntagonistsAnimalsBrain IschemiaCaffeineCentral Nervous System StimulantsCerebrovascular CirculationMaleOxygenRatsRats, Sprague-DawleyReceptor, Adenosine A2AReperfusion InjuryAdenosineAdenosine A2 Receptor AntagonistsCaffeineCentral Nervous System StimulantsOxygenReceptor, Adenosine A2AA2A receptorAdenosineBCCAOblood flowcaffeinefast-scan cyclic voltammetryFSCVin vivoischemia/reperfusion injuryoxygen

Identifiers

PMID30252436
PMCPMC7003050
OpenAlexW2893149238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.