Evidence map›Paper›PMID 30252141›Full record

ArticleAlcoholism, clinical and experimental research2018

Associations Between Alcohol Involvement and Drive for Thinness and Body Dissatisfaction in Adolescent Twins: A Bivariate Twin Study.

Jessica H Baker, Leigh C Brosof, Melissa A Munn-Chernoff, Paul Lichtenstein, Henrik Larsson, Hermine H Maes, Kenneth S Kendler

Registry-linked trialAbstract readTwin Study
In one paragraph

Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213883 (Characterizing Acute Exercise Response in Restrictive Eating Disorders), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06213883 nacompletednot on this mapstarted 2023, after this paper: background citation

Characterizing Acute Exercise Response in Restrictive Eating Disorders

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2023 to 2025Enrolled74ConditionsEating DisordersArmsBiobehavioral Response to in-lab exposure to physical activity
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Binge eating and alcohol consumption: an integrative review.Eating and weight disorders : EWD · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jessica H BakerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-3997-2398
Leigh C BrosofDepartment of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky.
Melissa A Munn-ChernoffDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-9368-9457
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hermine H MaesDepartment of Genetics, Virginia Commonwealth University, Richmond, Virginia.
Kenneth S KendlerDepartment of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.
University of North Carolina at Chapel Hill · USVirginia Commonwealth University · USKarolinska Institutet · SEÖrebro University · SEUniversity of Louisville · US

Funding

Genetic and Environmental Risk for Alcohol and Eating Disorders Across DevelopmentK01AA025113 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MUNN-CHERNOFF, MELISSA ANNE · 2017 to 2021
$773k
BIOMARKERS OF WEIGHT CHANGE IN ANOREXIA NERVOSAK01MH106675 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, JESSICA H · 2016 to 2019
$651k
NIAAA NIH HHS K01 AA025113NIMH NIH HHS K01 MH106675
6 · The paper itself

Abstract

backgroundAlcohol involvement has familial associations with bulimic symptoms (i.e., binge eating, inappropriate compensatory behaviors), with several studies indicating a genetic overlap between the two. It is unclear whether overlapping familial risk with alcohol involvement extends to other eating disorder symptoms. Understanding the genetic overlap between alcohol involvement and other eating disorder symptoms may aid in more targeted interventions for comorbid alcohol use-eating disorder symptoms. Thus, we investigated associations between alcohol involvement and 2 core eating disorder symptoms: drive for thinness and body dissatisfaction in adolescent female and male twins.

methodsWe assessed 3 levels of alcohol involvement: alcohol use in the last month, having ever been intoxicated, and alcohol intoxication frequency via self-report. The Eating Disorder Inventory-II assessed drive for thinness and body dissatisfaction. Sex-specific biometrical twin modeling examined the genetic overlap between alcohol involvement and eating disorder symptoms.

resultsPhenotypic associations between alcohol involvement, drive for thinness, and body dissatisfaction were significantly greater in girls compared with boys. A majority of the associations between alcohol involvement, drive for thinness, and body dissatisfaction in girls, but not boys, met our threshold for twin modeling (phenotypic r > 0.20). Moderate genetic correlations were observed between the 3 aspects of alcohol involvement and drive for thinness. Moderate genetic correlations were observed between alcohol use and intoxication frequency and body dissatisfaction.

conclusionsTogether with the literature on alcohol involvement and bulimic symptoms, these findings suggest a generalized association between alcohol involvement and eating disorder symptoms in girls, whereas this association may be symptom specific in boys. Genetic correlations indicate that the amount and direction of this genetic overlap differs across specific symptoms. When intervening on comorbid alcohol involvement and eating disorder symptoms, it may be important to target-specific eating disorder symptoms.

Indexed as

ThinnessAdolescentAlcohol DrinkingAlcoholic IntoxicationAlcohol-Related DisordersAnimalsBody Dysmorphic DisordersBody ImageBulimiaFeeding and Eating DisordersFemaleHumansMaleSex FactorsTwinsAlcohol UseComorbidityDisordered EatingEating DisorderTwin Study

Identifiers

PMID30252141
PMCPMC6214724
OpenAlexW2890933173

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.