ArticleThe Journal of comparative neurology2018
Input-output organization of the mouse claustrum.
Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- New functional insights from the monkey claustrum.National science review · 2026Review
- Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- A midbrain-cortical circuit mediated by a claustrum neuronal ensemble orchestrates drug-paired context memory processing.The Journal of clinical investigation · 2026Article
- The effect of psilocin on neurotransmitters release in the claustrum and on rat behavior.Pharmacological reports : PR · 2026Article
- Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice.Nature communications · 2026Article
- Similarities of neocortical deep layeriScience · 2025Article
- Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data.Nature methods · 2025Article
- The claustrum enhances neural variability by modulating the responsiveness of the prefrontal cortex.Nature communications · 2025Article
- Topographic organisation of the claustrum-amygdala-prefrontal circuitry in the common marmoset (Callithrix jacchus).Brain structure & function · 2025Article
- A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability.Nature communications · 2025Article
- Serotonin and psilocybin activate 5-HTNature communications · 2025Article
- Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice.Cell reports · 2025Article
- Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources.eLife · 2025Article
- The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?Life (Basel, Switzerland) · 2025Review
- Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex.Communications biology · 2025Article
- Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Progress in determining the precise organization and function of the claustrum (CLA) has been hindered by the difficulty in reliably targeting these neurons. To overcome this, we used a projection-based targeting strategy to selectively label CLA principal neurons. Combined with adeno-associated virus (AAV) and monosynaptic rabies tracing techniques, we systematically examined the pre-synaptic input and axonal output of this structure. We found that CLA neurons projecting to retrosplenial cortex (RSP) collateralize extensively to innervate a variety of higher-order cortical regions. No subcortical labeling was found, with the exception of sparse terminals in the basolateral amygdala (BLA). This pattern of output was similar to cingulate- and visual cortex-projecting CLA neurons, suggesting a common targeting scheme among these projection-defined populations. Rabies virus tracing directly demonstrated widespread synaptic inputs to RSP-projecting CLA neurons from both cortical and subcortical areas. The strongest inputs arose from classically defined limbic regions, including medial prefrontal cortex, anterior cingulate, BLA, ventral hippocampus, and neuromodulatory systems such as the dorsal raphe and cholinergic basal forebrain. These results suggest that the CLA may integrate information related to the emotional salience of stimuli and may globally modulate cortical state by broadcasting its output uniformly across a variety of higher cognitive centers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.