ArticleNano letters2018
Conformational Dynamics of a Single Protein Monitored for 24 h at Video Rate.
Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- PEC-DFM Hybrid-Sensor Based on Nanoparticle-Resolved Estimation for Sensitive and Reversible Glucose Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review of Machine Learning for Single-Particle Tracking: Methods, Challenges, and Biophysical Insights.Chemical & biomedical imaging · 2026Review
- Hidden Markov model analysis of fluorescence blinking in fluorescently labeled DNA.Scientific reports · 2026Article
- Design, Mechanisms, and Applications of DNA-Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures.Small methods · 2026Review
- Development of artificial photosystems based on designed proteins for mechanistic insights into photosynthesis.Protein science : a publication of the Protein Society · 2024Review
- Exploring Rotational Diffusion with Plasmonic Coupling.ACS photonics · 2024Article
- The Onset of Molecule-Spanning Dynamics in Heat Shock Protein Hsp90.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Single-Particle Plasmon Sensor to Monitor Proteolytic Activity in Real Time.ACS applied optical materials · 2023Article
- Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023Review
- Plasmonic Nanomaterials in Dark Field Sensing Systems.Nanomaterials (Basel, Switzerland) · 2023Review
- Insight into the Nucleotide Based Modulation of the Grp94 Molecular Chaperone Using Multiscale Dynamics.The journal of physical chemistry. B · 2023Article
- Dynamic Heterogeneity in the Optical Signals from Single Nano-Objects.The journal of physical chemistry. B · 2023Review
- Non-ergodicity of a globular protein extending beyond its functional timescale.Chemical science · 2022Article
- Light Extinction by Agglomerates of Gold Nanoparticles: A Plasmon Ruler for Sub-10 nm Interparticle Distances.Analytical chemistry · 2022Article
- Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics.Nature communications · 2021Article
- Article
- Critical Review: digital resolution biomolecular sensing for diagnostics and life science research.Lab on a chip · 2020Review
- Detailed balance for diffusion in a potential with trapping and forward-backward symmetry of trapping time distributions.The Journal of chemical physics · 2020Article
- Article
- Structural Consequences of Multisite Phosphorylation in the BAK1 Kinase Domain.Biophysical journal · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We use plasmon rulers to follow the conformational dynamics of a single protein for up to 24 h at a video rate. The plasmon ruler consists of two gold nanospheres connected by a single protein linker. In our experiment, we follow the dynamics of the molecular chaperone heat shock protein 90 (Hsp90), which is known to show "open" and "closed" conformations. Our measurements confirm the previously known conformational dynamics with transition times in the second to minute time scale and reveals new dynamics on the time scale of minutes to hours. Plasmon rulers thus extend the observation bandwidth 3-4 orders of magnitude with respect to single-molecule fluorescence resonance energy transfer and enable the study of molecular dynamics with unprecedented precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.