ArticleHuman brain mapping2019
White matter network connectivity deficits in developmental dyslexia.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Orthographic depth and developmental dyslexia: a meta-analytic study.Annals of dyslexia · 2021Pooled it
- Associations between READ1 deletion, reading proficiency, and white matter network organisation in children with and without developmental dyslexia.Brain structure & function · 2026Article
- Linking Attention Deficits to Difficulties in the Comprehension of Complex Syntax in Dyslexia.Dyslexia (Chichester, England) · 2026Article
- White Matter Networks of Phonological Awareness in Chinese Readers.Brain and behavior · 2025Article
- Reading and White Matter Development: A Systematic Review of Neuroplastic Changes in Literacy.Children (Basel, Switzerland) · 2025Review
- Development and Validity of the Adult Reading History Questionnaire (ARHQ) for Chinese.Dyslexia (Chichester, England) · 2025Article
- Modeling dyslexia in neurotypical adults by combining neuroimaging and neuromodulation techniques: a hypothesis paper.Frontiers in human neuroscience · 2025Article
- Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.BMC psychiatry · 2024Article
- Analysis of reading-task-based brain connectivity in dyslexic children using EEG signals.Medical & biological engineering & computing · 2024Article
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
- Investigating Dyslexia through Diffusion Tensor Imaging across Ages: A Systematic Review.Brain sciences · 2024Review
- A decade of white matter connectivity studies in developmental dyslexia.Psychoradiology · 2024Review
- Patterns of the left thalamus embedding into the connectome associated with reading skills in children with reading disabilities.Network neuroscience (Cambridge, Mass.) · 2024Article
- Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Theories about Developmental Dyslexia.Brain sciences · 2023Review
- Neural dissociation of visual attention span and phonological deficits in developmental dyslexia: A hub-based white matter network analysis.Human brain mapping · 2022Article
- Preoperative Navigated Transcranial Magnetic Stimulation: New Insight for Brain Tumor-Related Language Mapping.Journal of personalized medicine · 2022Review
- Elucidating the structural-functional connectome of language in glioma-induced aphasia using nTMS and DTI.Human brain mapping · 2022Article
- Voxel and surface based whole brain analysis shows reading skill associated grey matter abnormalities in dyslexia.Scientific reports · 2021Article
- Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study.Nature and science of sleep · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
A number of studies have shown an abnormal connectivity of certain white matter pathways in developmental dyslexia, as well as correlations between these white matter pathways and behavioral deficits. However, whether developmental dyslexia presents broader white matter network connectivity disruption is currently unknown. The present study reconstructed white matter networks for 26 dyslexic children (11.61 ± 1.31 years) and 31 age-matched controls (11.49 ± 1.36 years) using constrained spherical deconvolution tractography. Network-based statistics (NBS) analysis was performed to identify network connectivity deficits in dyslexic individuals. Network topological features were measured based on graph theory to examine whether these parameters correlate with literacy skills, and whether they explain additional variance over previously established white matter connectivity abnormalities in dyslexic children. The NBS analysis identified a network connecting the left-occipital-temporal cortex and temporo-parietal cortex that had decreased streamlines in dyslexic children. Four network topological parameters (clustering coefficient, local efficiency, transitivity, and global efficiency) were positively correlated with literacy skills of dyslexic children, and explained a substantial proportion of additional variance in literacy skills beyond connectivity measures of white matter pathways. This study for the first time reports a disconnection in a local subnetwork in the left hemisphere in dyslexia and shows that the global white matter network topological properties contribute to reduced literacy skills in dyslexic children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.