ArticleHuman brain mapping2019
Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Functional magnetic resonance imaging insights into nociceptive signal processing network in rat lumbar spinal cord.Pain reports · 2026Article
- Machine Learning-Based Clustering of Layer-Resolved fMRI Activation and Functional Connectivity Within the Primary Somatosensory Cortex in Nonhuman Primates.Human brain mapping · 2025Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Detection and characterization of resting state functional networks in squirrel monkey brain.Cerebral cortex communications · 2023Article
- Cortical depth-dependent human fMRI of resting-state networks using EPIK.Frontiers in neuroscience · 2023Article
- Pre-processing of Sub-millimeter GE-BOLD fMRI Data for Laminar Applications.Frontiers in neuroimaging · 2022Article
- Contribution of animal models toward understanding resting state functional connectivity.NeuroImage · 2021Review
- Optimization of a quadrature birdcage coil for functional imaging of squirrel monkey brain at 9.4T.Magnetic resonance imaging · 2021Article
- Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy.Scientific reports · 2021Article
- Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.Human brain mapping · 2019Article
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Authors and funding
6 authors.
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Abstract
Whereas resting state blood oxygenation-level dependent (BOLD) functional MRI has been widely used to assess functional connectivity between cortical regions, the laminar specificity of such measures is poorly understood. This study aims to determine: (a) whether the resting state functional connectivity (rsFC) between two functionally related cortical regions varies with cortical depth, (b) the relationship between layer-resolved tactile stimulus-evoked activation pattern and interlayer rsFC pattern between two functionally distinct but related somatosensory areas 3b and 1, and (c) the effects of spatial resolution on rsFC measures. We examined the interlayer rsFC between areas 3b and 1 of squirrel monkeys under anesthesia using tactile stimulus-driven and resting state BOLD acquisitions at submillimeter resolution. Consistent with previous observations in the areas 3b and 1, we detected robust stimulus-evoked BOLD activations with foci were confined mainly to the upper layers (centered at 21% of the cortical depth). By carefully placing seeds in upper, middle, and lower layers of areas 3b and 1, we observed strong rsFC between upper and middle layers of these two areas. The layer-resolved activation patterns in areas 3b and 1 agree with their interlayer rsFC patterns, and are consistent with the known anatomical connections between layers. In summary, using BOLD rsFC pattern, we identified an interlayer interareal microcircuit that shows strong intrinsic functional connections between upper and middle layer areas 3b and 1. RsFC can be used as a robust invasive tool to probe interlayer corticocortical microcircuits.
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