ArticleHuman brain mapping2019
Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroimaging and machine learning in eating disorders: a systematic review.Eating and weight disorders : EWD · 2025Pooled it
- Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.Clinical psychology review · 2020Pooled it
- Functional connectivity and treatment response in obesity and eating disorders: Current evidence and empirical data.Reviews in endocrine & metabolic disorders · 2026Review
- Brain Connectivity and Machine Learning Approaches to assess the underlying neurobiology and prediction accuracy of anorexia nervosa: A replication study.Psychiatry research. Neuroimaging · 2026Article
- Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Chronic Co-administration of Methylphenidate and Fluoxetine Reduces Striatal NMDA Receptor Binding in Adolescent Rats.Neurochemical research · 2026Article
- Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression.Translational psychiatry · 2025Article
- Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.The International journal of eating disorders · 2025Article
- Exploring Habits in Anorexia Nervosa: Promise, Pitfalls, and Progress.Current psychiatry reports · 2025Review
- Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Reduced dorsal fronto-striatal connectivity at rest in anorexia nervosa.Psychological medicine · 2024Article
- Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.Nature communications · 2024Article
- Article
- Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity.Molecular psychiatry · 2023Article
- Habits and Persistent Food Restriction in Patients with Anorexia Nervosa: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2023Article
- Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes.Psychological medicine · 2023Article
- Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa.Translational psychiatry · 2023Article
- Comparing the test-retest reliability of resting-state functional magnetic resonance imaging metrics across single band and multiband acquisitions in the context of healthy aging.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p < .01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = -.58, CI: -.83, -.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.
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