ArticleHuman brain mapping2019
From eyes-closed to eyes-open: Role of cholinergic projections in EC-to-EO alpha reactivity revealed by combining EEG and MRI.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- A systematic review of resting-state EEG across the menstrual cycle and its mental health relevance.Archives of women's mental health · 2026Pooled it
- Electroencephalography, Magnetoencephalography, and Cognitive Reserve: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Pooled it
- A randomized controlled study of remote computerized cognitive, neurofeedback, and combined training in the treatment of children with attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2023Trial
- Alpha Reactivity Dynamics Reveal Multi-System Variability Without Global Alpha Slowing in Fragile X Syndrome.Research square · 2026Article
- Virtual brain and electroencephalography explain the variance of memory alterations in mild cognitive impairment.Alzheimer's research & therapy · 2026Article
- Quantitative electroencephalography as a next-generation tool in neurodiagnostics: significance, clinical applications, and practical interpretative frameworks.Frontiers in neuroscience · 2026Review
- Electroacupuncture alleviates cognitive impairment in mice with vascular dementia by regulating the cholinergic vasodilation system.Frontiers in aging neuroscience · 2026Article
- EEG alpha reactivity in cognitive aging and dementia: clinical implications and cholinergic mechanisms.Frontiers in human neuroscience · 2026Review
- Electrophysiological evaluation of cognitive intervention outcomes in children with attention deficit/hyperactivity disorder.Frontiers in neuroscience · 2026Article
- Selective Effects of Ongoing Alpha-Band Activity on Magno- and Parvo-Mediated Detection.Psychophysiology · 2025Article
- States, traits, and the resting state EEG task aftereffect.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Visual cortical activity in Charles Bonnet syndrome: testing the deafferentation hypothesis.Journal of neurology · 2025Article
- Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer's Disease.International journal of molecular sciences · 2025Article
- The fluctuations of alpha power: Bimodalities, connectivity, and neural mass models.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Age-related changes in neural oscillations vary as a function of brain region and frequency band.Frontiers in aging neuroscience · 2025Article
- Tracking EEG network dynamics through transitions between eyes-closed, eyes-open, and task states.Scientific reports · 2024Article
- Functionally annotated electrophysiological neuromarkers of healthy ageing and memory function.Human brain mapping · 2024Article
- The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations.Frontiers in aging neuroscience · 2024Review
- Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity.British journal of anaesthesia · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Alpha rhythm (8 to 12 Hz) observed in EEG over human posterior cortex is prominent during eyes-closed (EC) resting and attenuates during eyes-open (EO) resting. Research shows that the degree of EC-to-EO alpha blocking or alpha desynchronization, termed alpha reactivity here, is a neural marker of cognitive health. We tested the role of acetylcholine in EC-to-EO alpha reactivity by applying a multimodal neuroimaging approach to a cohort of young adults and a cohort of older adults. In the young cohort, simultaneous EEG-fMRI was recorded from twenty-one young adults during both EO and EC resting. In the older cohort, functional MRI was recorded from forty older adults during EO and EC resting, along with FLAIR and diffusion MRI. For a subset of twenty older adults, EEG was recorded during EO and EC resting in a separate session. In both young and older adults, functional connectivity between the basal nucleus of Meynert (BNM), the major source of cortical acetylcholine, and the visual cortex increased from EC to EO, and this connectivity increase was positively associated with alpha reactivity; namely, the stronger the BNM-visual cortex functional connectivity increase from EC to EO, the larger the EC-to-EO alpha desynchronization. In older adults, lesions of the fiber tracts linking BNM and visual cortex quantified by leukoaraiosis volume, associated with reduced alpha reactivity. These findings support a role of acetylcholine and particularly cholinergic pathways in mediating EC-to-EO alpha reactivity and suggest that impaired alpha reactivity could serve as a marker of the integrity of the cholinergic system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.