Evidence map›Paper›PMID 30251690›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

CoQ

Giulio Kleiner, Emanuele Barca, Marcello Ziosi, Valentina Emmanuele, Yimeng Xu, Agustin Hidalgo-Gutierrez, Changhong Qiao, Saba Tadesse, Estela Area-Gomez, Luis C Lopez and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders.Handbook of experimental pharmacology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Coenzyme QFree radical biology & medicine · 2025
    Article
  9. Article
  10. SQOR as a metabolic rheostat of HFrontiers in cell and developmental biology · 2025
    Review
  11. Understanding coenzyme Q.Physiological reviews · 2024
    Review
  12. Article
  13. Regulation of Mitochondrial Respiration by Hydrogen Sulfide.Antioxidants (Basel, Switzerland) · 2023
    Review
  14. New Insights on the Uptake and Trafficking of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Cysteine as a Multifaceted Player in Kidney, theMolecules (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Giulio KleinerDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Emanuele BarcaDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Marcello ZiosiDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Valentina EmmanueleDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Yimeng XuDepartment of Pathology, Columbia University Medical Center, New York, NY, United States.
Agustin Hidalgo-GutierrezDepartment of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
Changhong QiaoIrving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY, United States.
Saba TadesseDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Estela Area-GomezDepartment of Neurology, Columbia University Medical Center, New York, NY, United States.
Luis C LopezDepartment of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
Catarina M QuinziiDepartment of Neurology, Columbia University Medical Center, New York, NY, United States. Electronic address: cmq2101@cumc.columbia.edu.
Columbia University Irving Medical Center · USUniversidad de Granada · ES

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
The North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VAN HOVE, JOHAN L · 2011 to 2023
$17.5M
Tech-CoreP01HD080642 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUINZII, CATARINA M. · 2014 to 2018
$7.8M
Role of C99 in the regulation of lipid metabolism- Relevance to Alzheimer's diseaseR01AG056387 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AREA GOMEZ, ESTELA · 2017 to 2021
$2.1M
Endoplasmic Reticulum Mitochondrial membranes in Alzheimer's diseaseK01AG045335 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AREA GOMEZ, ESTELA · 2014 to 2018
$567k
NCATS NIH HHS UL1 TR001873NIA NIH HHS K01 AG045335NIA NIH HHS R01 AG056387NICHD NIH HHS P01 HD080642NIH HHS P01 HD080642-01NIH HHS UL1TR001873NINDS NIH HHS U54 NS078059
6 · The paper itself

Abstract

Nephrotic syndrome (NS), a frequent chronic kidney disease in children and young adults, is the most common phenotype associated with primary coenzyme Q

Indexed as

Alkyl and Aryl TransferasesAnimalsAntioxidantsAtaxiaDisease Models, AnimalHeLa CellsHumansHydrogen SulfideKidneyMetabolic Networks and PathwaysMiceMice, TransgenicMitochondriaMitochondrial DiseasesMuscle WeaknessNephrotic SyndromeAlkyl and Aryl TransferasesAntioxidantscoenzyme Q10Hydrogen SulfideidebenoneOxidoreductases Acting on Sulfur Group Donorsprenyl diphosphate synthase subunit 2, mouseReactive Oxygen SpeciesSQOR protein, humanUbiquinoneCoenzyme Q(10)CoQ deficiencyMitochondriaOxidative stressSulfides

Identifiers

PMID30251690
PMCPMC6181133
OpenAlexW2889752229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.