ArticleNanotoxicology2018
Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells.
Article in Nanotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Imaging and speciation of intracellular metallic implant debris using synchrotron-based X-ray fluorescence micro-spectroscopy: a study of two cases.Scientific reports · 2025Article
- Sensing with Thermally Reduced Graphene Oxide under Repeated Large Multi-Directional Strain.Sensors (Basel, Switzerland) · 2024Article
- Dynamic microfluidic bioreactor-Hip simulator (DMBH) system for implant toxicity monitoring.Biotechnology and bioengineering · 2021Article
- The role of Vitamin E in hip implant-related corrosion and toxicity: Initial outcome.Journal of the mechanical behavior of biomedical materials · 2021Article
- The Mechanism of Metallosis After Total Hip Arthroplasty.Regenerative engineering and translational medicine · 2021Article
- Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels - An in-vitro study.Journal of the mechanical behavior of biomedical materials · 2021Article
- Article
- In Vitro Evidence for Cell-Accelerated Corrosion Within Modular Junctions of Total Hip Replacements.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces.Acta biomaterialia · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Physico-chemical characteristics of the CoCrMo degradation products have played an important role in cytotoxicity and clinical complications on the orthopedic patients who have metal implants. Previous studies have limited reflection on the physicochemical characteristics of the degradation products generated in vivo, which are very different from individual metal particles and/or ions obtained from different commercial sources. In this study, we aimed to understand the differences in toxicity induced by the degradation products in as-synthesized form as well as those obtained after post-processing. The degradation products were generated using a hip-simulator by maintaining physiological conditions closer to in vivo and separated into two batches, one with processing by washing and drying called processed degradation products (PDP) and another batch as 'as-synthesized' degradation product (DP). We studied the dose-dependent toxicity response by neural cells derived from induced pluripotent stem cells. The results of the study show that as-synthesized DPs are more toxic to neural cells even at lower concentrations studied with evident low TC50 (1-5 μg/ml) concentrations compared to PDP (25 μg/ml). Flow cytometric analysis showed a significant (p<.01) increase in uptake of the particles after 24 h and corresponding ROS production in DP-treated cells. RT-PCR analysis of oxidative specific gene expression showed, elevated mRNA levels of NADPH oxidase-1, nuclear transcription factor, superoxide dismutase-2 and glutaredoxin-2 in DP-treated cells after 6 h. The results of the study provided a clear evidence of the differential response of neural cells on the degradation products as a function of concentrations and their chemical nature.
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