ArticleArthritis & rheumatology (Hoboken, N.J.)2019
Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Rheumatoid Arthritis Has Won the Battle but Not the War: How Many Joints Will We Save Tomorrow?Medicina (Kaunas, Lithuania) · 2023Review
- Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis.Scientific reports · 2022Article
- Accelerated atherosclerosis in premenopausal women with rheumatoid arthritis - 15-year follow-up.Bosnian journal of basic medical sciences · 2021Article
- Cardiovascular effects of approved drugs for rheumatoid arthritis.Nature reviews. Rheumatology · 2021Review
- Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk.Journal of clinical medicine · 2021Article
- Autoimmunity in 2019.Clinical reviews in allergy & immunology · 2020Review
- Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study.Scientific reports · 2020Article
- Immunogenetics of Atherosclerosis-Link between Lipids, Immunity, and Genes.Current atherosclerosis reports · 2020Review
- Carotid plaques in adult rheumatoid arthritis patients; association with paroxonase 1 enzymatic activity and Q192R paroxonase 1 gene polymorphism.Molecular biology reports · 2020Article
- Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis.Frontiers in genetics · 2020Article
- Article
- IL-6: linking chronic inflammation and vascular calcification.Nature reviews. Rheumatology · 2019Article
Corrections and comments
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Authors and funding
37 authors at 20 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the genetic background influencing the development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA).
methodsWe performed a genome-wide association study (GWAS) in which, after quality control and imputation, a total of 6,308,944 polymorphisms across the whole genome were analyzed in 2,989 RA patients of European origin. Data on subclinical atherosclerosis, obtained through assessment of carotid intima-media thickness (CIMT) and presence/absence of carotid plaques by carotid ultrasonography, were available for 1,355 individuals.
resultsA genetic variant of the RARB gene (rs116199914) was associated with CIMT values at the genome-wide level of significance (minor allele [G] β coefficient 0.142, P = 1.86 × 10
conclusionThe present findings strongly suggest that genetic variation within RARB contributes to the development of subclinical atherosclerosis in patients with RA.
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