ArticleJournal of the American Geriatrics Society2018
Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty and testosterone level in older adults: a systematic review and meta-analysis.European geriatric medicine · 2022Pooled it
- Gender differences for frailty in HIV-infected patients on stable antiretroviral therapy and with an undetectable viral load.PloS one · 2019Trial
- Longer duration of intact hypothalamic-pituitary-gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs.Scientific reports · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Reproductive factors and risk of physical frailty among Chinese women living in Singapore.The journal of nutrition, health & aging · 2024Article
- Reproductive factors and their association with physical and comprehensive frailty in middle-aged and older women: a large-scale population-based study.Human reproduction open · 2024Article
- Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer.Current oncology (Toronto, Ont.) · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo determine whether women with surgical menopause have a higher risk of frailty than naturally menopausal women.
designProspective cohort study with up to 18 years of follow-up.
settingFour U.S clinical centers.
participantsCommunity-dwelling white women aged 65 and older (mean 71.2±5.2) enrolled in the Study of Osteoporotic Fractures (N=7,699). MEASUREMENTS: Surgical menopause was based on participant self-report of having undergone bilateral oophorectomy before menopause. The outcome was incident frailty, classified as robust, prefrail, frail, or death at 4 follow-up interviews, conducted 6 to 18 years after baseline. Information on baseline serum total testosterone concentrations was available for 541 participants.
resultsAt baseline, 12.6% reported surgical menopause. Over the follow-up period, 22.0% died, and 10.1% were classified as frail, 39.7% as prefrail, and 28.3% as robust. Surgically menopausal women had significantly lower total serum testosterone levels (13.2 ± 7.8 ng/dL) than naturally menopausal women (21.7 ± 14.8 ng/dL) (p=0.000), although they were not at greater risk of frailty (adjusted odds ratio (aOR)=0.94, 95% confidence interval (CI)=0.72-1.22), prefrailty (aOR=0.96, 95% CI=0.80-1.10), or death (aOR=1.17, 95% CI=0.97-1.42) after adjusting for age, body mass index, and number of instrumental activity of daily living impairments. There was no evidence that oral estrogen use modified these associations.
conclusionIn postmenopausal women, surgical menopause was not associated with greater risk for frailty than natural menopause, even in the absence of estrogen therapy. Future prospective studies are needed to investigate hormonal mechanisms involved in development of frailty in older postmenopausal women. J Am Geriatr Soc 66:2172-2177, 2018.
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