Evidence map›Paper›PMID 30251251›Full record

ArticleJournal of the American Geriatrics Society2018

Association Between Subclinical Brain Infarcts and Functional Decline Trajectories.

Mandip S Dhamoon, Ying-Kuen Cheung, Janet T DeRosa, Jose Gutierrez, Yeseon P Moon, Ralph L Sacco, Mitchell S V Elkind, Clinton B Wright

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Vascular Cognitive Impairment (VCI).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mandip S DhamoonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
Ying-Kuen CheungDepartment of Biostatistics, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York.
Janet T DeRosaDepartment of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York.
Jose GutierrezDepartment of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York.
Yeseon P MoonDepartment of Biostatistics, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York.
Ralph L SaccoMcKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, Florida.
Mitchell S V ElkindDepartment of Epidemiology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York.
Clinton B WrightNational Institutes of Health, Bethesda, Maryland.

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Inflammatory and Infectious Burden and Risk of StrokeR01NS048134 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ELKIND, MITCHELL S · 2004 to 2008
$1.5M
The trajectory of functional status and quality of life before and after strokeK23NS079422 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DHAMOON, MANDIP SINGH · 2013 to 2017
$917k
NINDS NIH HHS K23 NS079422NINDS NIH HHS K23NS079422NINDS NIH HHS R01 29993NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS48134
6 · The paper itself

Abstract

objectivesTo test associations between subclinical brain infarcts (SBIs) and functional decline independently of intervening clinical vascular events and other vascular risk factors.

designLongitudinal follow-up for a mean 7.3 years. Generalized estimating equation models were used to test associations between SBIs, number of perivascular spaces (PVSs), baseline Barthel Index (BI), and change in BI, adjusting for sociodemographic, vascular, and cognitive risk factors and for stroke and myocardial infarction occurring during follow-up.

settingPopulation-based prospective cohort study.

participantsStroke-free individuals from the racially and ethnically diverse Northern Manhattan Study (N=1,290). MEASUREMENTS: Annual functional assessments using the BI (range 0-100).

resultsMean age was 70.6 ± 9.0, 40% of participants were male, 66% were Hispanic, 193 (16%) had SBIs, and 508 (42%) had large PVSs. SBIs were not associated with baseline BI. In a fully adjusted model, there was a change in BI of -0.85 points per year (95% confidence interval (CI)=-1.01 to -0.69); those with SBI had an additional change in BI 0f -0.88 points (95% CI=-1.43 to -0.32). There were no associations between PVS and baseline BI or change in BI.

conclusionIn a large population-based study, we found a strong and independent association between "subclinical" markers of cerebrovascular injury and important clinical, person-centered functional trajectories. Future research could clarify the evolution of such subclinical markers over time and test strategies to prevent their progression and minimize related disability. J Am Geriatr Soc 66:2144-2150, 2018.

Indexed as

AgedAge FactorsBrain InfarctionDisease ProgressionEthnicityFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMedicareProspective StudiesQuality of LifeSex FactorsStrokeUnited Statesdisabilityepidemiologysubclinical brain infarct

Identifiers

PMID30251251
PMCPMC6235693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.