Evidence map›Paper›PMID 30251194›Full record

ArticleCEN case reports2019

Crohn's disease following rituximab treatment in a patient with refractory nephrotic syndrome.

Keishi Morita, Takayuki Shibano, Kohei Maekawa, Masuji Hattori, Nobuyuki Hida, Shiro Nakamura, Yasuhiro Takeshima

Open access · greenAbstract readCase Reports
In one paragraph

Article in CEN case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Enhanced therapeutic efficacy of granulocyte/monocyte adsorption in rats with drug-induced colitis : Insights from a downsized bead column and newly formed B cells.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Keishi MoritaDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan. xyzw0412@yahoo.co.jp.ORCID http://orcid.org/0000-0002-6853-1620
Takayuki ShibanoDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan.
Kohei MaekawaDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan.
Masuji HattoriDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan.
Nobuyuki HidaDivision of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan.
Shiro NakamuraDivision of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan.
Yasuhiro TakeshimaDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan.
Hyogo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rituximab (RTX) is increasingly used for the treatment of refractory nephrotic syndrome due to its inhibitory effect on B cells which extends the period of remission, while lowering the dose of steroids needed for disease management. However, RTX can lead to various side effects, including Crohn's disease. Herein, we describe a case of a 15-year-old boy with refractory nephrotic syndrome diagnosed at age 9 years who developed Crohn's disease following RTX treatment. RTX was initiated in this patient at the age of 13 years 6 months due to occurrence of 12 relapses of nephrotic syndrome over a 4-year period, despite treatment using cyclosporine, steroid pulse therapy, and mycophenolate mofetil. The patient received 4 doses of RTX over a 2-year period (dose, 375 mg/m

Indexed as

AdolescentCapsule EndoscopyColonoscopyCrohn DiseaseGastrointestinal AgentsHumansImmunologic FactorsInfliximabMaleNephrotic SyndromeRituximabGastrointestinal AgentsImmunologic FactorsInfliximabRituximabCrohn’s diseaseInfliximabRefractory nephrotic syndromeRituximab

Identifiers

PMID30251194
PMCPMC6361080
OpenAlexW2893253322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.