ArticleBrain imaging and behavior2020
Medial temporal lobe volumes in late-life depression: effects of age and vascular risk factors.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Psychosocial factors and hippocampal subfields: The Medea-7T study.Human brain mapping · 2023Pooled it
- Depression and anxiety in vascular dementia: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Executive Function Deficit and Medial Temporal Lobe Atrophy in Late-Life Depression: Pathophysiological and Therapeutic Implications.Alpha psychiatry · 2026Article
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Gray and white matter differences in the medial temporal lobe in late-life depression: a multimodal PET-MRI investigation.Psychological medicine · 2025Article
- Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.Brain communications · 2025Article
- Article
- Altered structural hippocampal intra-networks in a general elderly Japanese population with mild cognitive impairment.Scientific reports · 2023Article
- Cognitive phenotypes in late-life depression.International psychogeriatrics · 2023Observational
- Executive function deficits and medial temporal lobe atrophy in late-life depression and Alzheimer's disease: a comparative study.Frontiers in psychiatry · 2023Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Pathomechanisms of Vascular Depression in Older Adults.International journal of molecular sciences · 2021Review
- Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activatedThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Associations of AT(N) biomarkers with neuropsychiatric symptoms in preclinical Alzheimer's disease and cognitively unimpaired individuals.Translational neurodegeneration · 2021Review
- Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway.Frontiers in psychiatry · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Substantial work associates late-life depression with hippocampal pathology. However, there is less information about differences in hippocampal subfields and other connected temporal lobe regions and how these regions may be influenced by vascular factors. Individuals aged 60 years or older with and without a DSM-IV diagnosis of Major Depressive Disorder completed clinical assessments and 3 T cranial MRI using a protocol allowing for automated measurement of medial temporal lobe subfield volumes. A subset also completed pseudo-continuous arterial spin labeling, allowing for the measurement of hippocampal cerebral blood flow. In 59 depressed and 21 never-depressed elders (mean age = 66.4 years, SD = 5.8y, range 60-86y), the depressed group did not exhibit statistically significant volumetric differences for the total hippocampus or hippocampal subfields but did exhibit significantly smaller volumes of the perirhinal cortex, specifically in the BA36 region. Additionally, age had a greater effect in the depressed group on volumes of the cornu ammonis, entorhinal cortex, and BA36 region. Finally, both clinical and radiological markers of vascular risk were associated with smaller BA36 volumes, while reduced hippocampal blood flow was associated with smaller hippocampal and cornu ammonis volumes. In conclusion, while we did not observe group differences in hippocampal regions, we observed group differences and an effect of vascular pathology on the BA36 region, part of the perirhinal cortex. This is a critical region exhibiting atrophy in prodromal Alzheimer's disease. Moreover, the observed greater effect of age in the depressed groups is concordant with past longitudinal studies reporting greater hippocampal atrophy in late-life depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.