ArticleClinical journal of gastroenterology2019
Proton-pump inhibitor-induced fundic gland polyps with hematemesis.
Article in Clinical journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Sporadic Fundic Gland Polyposis Associated With Long-Term Proton Pump Inhibitor Use: A Case Report.Cureus · 2025Article
- Long-term endoscopic change of gastric polyp associated with administration of vonoprazan.Clinical journal of gastroenterology · 2024Article
- Drug-induced mucosal alterations observed during esophagogastroduodenoscopy.World journal of gastroenterology · 2024Review
- Clinicopathologic Correlation of Large Gastric Polyps in an Elderly Female: Case Report and Review of the Literature.Cureus · 2024Article
- Long-term vonoprazan administration causes gastric fundic gland-type hyperplastic polyps and chronic bleeding.Clinical journal of gastroenterology · 2023Article
- Gastroduodenal Intussusception Due to Vonoprazan-induced Gastric Polyps.Internal medicine (Tokyo, Japan) · 2022Article
- Ultrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats.Anatomical science international · 2021Article
- Disappearance of Gastric Hyperplastic Polyps after the Discontinuation of Proton Pump Inhibitor in a Patient with Liver Cirrhosis.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fundic gland polyps (FGPs) are generally considered benign. Proton-pump inhibitors (PPIs) are used worldwide as first-line therapy for gastroesophageal reflux disease and nonsteroidal anti-inflammatory drug-induced ulcer treatment. Long-term use of PPIs increases the risk of FGP development. We report an extremely rare case of PPI-induced FGPs with hematemesis. A 37-year-old woman taking daily rabeprazole presented to the hospital with a complaint of hematemesis and tarry stools. Esophagogastroduodenoscopy (EGD) revealed > 20 pedunculated polyps in the gastric body and fundus. Histological examination showed multiple fragments of fundic gland mucosa with dilated glands. Based on these findings and the clinical history, FGPs were diagnosed. Rabeprazole use was discontinued. Repeat EGD performed 9 months later showed a significant decrease in the number and size of the polyps. FGPs are small polyps typically located in the gastric corpus and fundus. They are commonly reported in patients in their 60s and predominantly in females. We conclude that PPI use is a risk factor for the development of FGPs and hematemesis.
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Registered trials
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