Evidence map›Paper›PMID 30250940›Full record

ArticleUltrasound international open2018

Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type.

Kaoru Kobayashi, Tomoko Fujimoto, Hisashi Ota, Mitsuyoshi Hirokawa, Tomonori Yabuta, Hiroo Masuoka, Mitsuhiro Fukushima, Takuya Higashiyama, Minoru Kihara, Yasuhiro Ito and 2 more

Open access · goldAbstract read
In one paragraph

Article in Ultrasound international open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  13. Molecular Aspects of Thyroid Calcification.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kaoru KobayashiDepartment of Surgery, Kuma Hospital, Kobe, Japan.
Tomoko FujimotoDepartment of Clinical Laboratory, Kuma Byoin, Kobe, Japan.
Hisashi OtaDepartment of Clinical Laboratory, Kuma Byoin, Kobe, Japan.
Mitsuyoshi HirokawaDepartment of Diagnostic Pathology, Kuma Hospital, Kobe, Japan.
Tomonori YabutaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Hiroo MasuokaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Mitsuhiro FukushimaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Takuya HigashiyamaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Minoru KiharaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Yasuhiro ItoDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Akihiro MiyaDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Akira MiyauchiDepartment of Surgery, Kuma Byoin, Kobe, Japan.
Kuma Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the study is to clarify the prevalence of calcifications within thyroid tumors on ultrasonography as well as the relationship between the calcification and histopathological types. MATERIALS AND

methodsCalcifications were classified into 6 (or 8) types according to their shape, size, and region. The prevalence of calcifications and types were investigated in new outpatients and patients who underwent thyroid surgery.

resultsAmong 2,902 nodules in 2,678 new outpatients, 747 nodules (26%) had calcifications. The types showed a wide distribution. Among 941 patients with papillary carcinoma (PC), 725 patients (77%) had calcifications, and the types showed a wide distribution. 18 patients with the diffuse sclerosing variant of PC only showed punctate microcalcifications in the parenchyma (100%), 32 patients with the cyst-forming type of PC mostly fragmentary and massive types (100%), and 161 metastatic lymph nodes from PC mostly punctate microcalcifications and fragmentary types (48%). Among 337 patients with follicular carcinoma, 79 patients (23%) had calcifications, and the types were mostly fragmentary, massive, and egg-shell types. Among 41 patients with undifferentiated carcinoma, 33 patients (80%) presented with calcifications, which were mostly the massive and egg-shell types. Among 137 patients with medullary carcinoma, 99 patients (72%) had calcification, and the types showed a wide distribution. None of 173 patients with primary thyroid lymphoma had calcifications (0%).

conclusionCalcifications on ultrasonography can be one of the characteristic findings and a full understanding of the prevalence of calcifications and types will markedly contribute to the ultrasonic diagnosis of thyroid tumors.

Indexed as

calcificationshistopahologythyroidtumorultrasound

Identifiers

PMID30250940
PMCPMC6148317
OpenAlexW2841647921

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.