Evidence map›Paper›PMID 30250879›Full record

ArticleMolecular & cellular oncology2018

Cellular differentiation: Potential insight into butyrate paradox?

Stacy H Ryu, Gerard E Kaiko, Thaddeus S Stappenbeck

Open access · bronzeAbstract read
In one paragraph

Article in Molecular & cellular oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. The metabolic profiles of cancer stem cells.Stem cell research & therapy · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. A Model of Butyrate Activity and Resistance in CRC.Journal of cellular and molecular medicine · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Colon mucus in colorectal neoplasia and beyond.World journal of gastroenterology · 2022
    Review
  12. Review
  13. Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site.International journal of molecular sciences · 2021
    Review
  14. The role of butyrate in surgical and oncological outcomes in colorectal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
  15. BRAFJournal of experimental & clinical cancer research : CR · 2020
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stacy H RyuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Gerard E KaikoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently demonstrated that cellular responses to butyrate depend on the differentiation status of the colonic epithelium. Here, we apply the implications of these findings to cancer biology and discuss discrepancies in the effects of butyrate on cancer progression.

Indexed as

ButyratecolonocytedifferentiationFoxo3HDAC

Identifiers

PMID30250879
PMCPMC6150034
OpenAlexW2481913907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.