Evidence map›Paper›PMID 30250862›Full record

ArticleAnnals of clinical and translational neurology2018

Transient ischemia facilitates neuronal chloride accumulation and severity of seizures.

Thomas Blauwblomme, Volodymyr Dzhala, Kevin Staley

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
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  6. The role ofJournal of pharmaceutical analysis · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Thomas BlauwblommeDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114.
Volodymyr DzhalaDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114.
Kevin StaleyDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114.
Massachusetts General Hospital · USHarvard University · US

Funding

Neuronal Chloride distribution by displacementR01NS040109 · NINDS · UNIVERSITY OF COLORADO DENVER · PI STALEY, KEVIN J. · 2000 to 2020
$7.2M
NINDS NIH HHS R01 NS040109
6 · The paper itself

Abstract

objectivePreceding oxygen glucose deprivation (OGD) and ongoing seizures have both been reported to increase neuronal chloride concentration ([Cl

methodsThe effects of OGD on [Cl

resultsSeizures initially increased during OGD, followed by suppression. On reperfusion, seizure frequency and [Cl

interpretation[Cl

Identifiers

PMID30250862
PMCPMC6144438
OpenAlexW2831053597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.