ArticleAnnals of clinical and translational neurology2018
Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients.Brain sciences · 2025Article
- A Novel Approach to Screen for Somatosensory Evoked Potentials in Critical Care.Neurocritical care · 2024Article
- Auditory stimulation and deep learning predict awakening from coma after cardiac arrest.Brain : a journal of neurology · 2023Article
- Comatose Patients After Cardiopulmonary Resuscitation: An Analysis Based on Quantitative Methods of EEG Reactivity.Frontiers in neurology · 2022Article
- Evoked and Event-Related Potentials as Biomarkers of Consciousness State and Recovery.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2022Review
- Automatic Sensory Predictions: A Review of Predictive Mechanisms in the Brain and Their Link to Conscious Processing.Frontiers in human neuroscience · 2021Review
- Brain functional connectivity during the first day of coma reflects long-term outcome.NeuroImage. Clinical · 2020Article
- EEG-based outcome prediction after cardiac arrest with convolutional neural networks: Performance and visualization of discriminative features.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProminent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients.
methodsElectroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset.
resultsMultivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68).
interpretationOur results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.
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Registered trials
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