ArticleAnesthesiology and pain medicine2018
The Association Between Constipation or Stool Consistency and Pain Severity in Patients With Chronic Pain.
Article in Anesthesiology and pain medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Unravelling the spine-gut-pain connection: chronic musculoskeletal pain and digestive dysfunction in a large-scale population-based cohort of 110,685 individuals.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Association Between Systemic Symptoms and Recovery in Acute Low Back Pain: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Differences in Gut Microbiota Composition Depending on the Site of Pain in Patients with Chronic Pain.Journal of pain research · 2025Article
- Constipation and pain in Parkinson's disease: a clinical analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.Bioscience of microbiota, food and health · 2024Article
- Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis.Frontiers in microbiology · 2024Article
- Biopsychosocial Model and Perceived Constipation Severity According to the Constipation Phenotype.Digestive diseases and sciences · 2021Article
- Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteria can influence a variety of gut functions. Some studies showed that stool consistency and constipation were associated with gut microbiome (GM) composition, and enterotype, dysbiosis. Growing evidence indicates the significant role of GM in the homeostatic function of the host body. The GM may regulate multiple neurochemical and neurometabolic pathways. Chronicity of the pain is actively modulated at the molecular to the network level by means of several neurotransmitters. The GM to some extent can affect pain perception.
objectivesThe current study aimed at investigating the relationship between constipation state or usual stool form and pain severity of patients with chronic pain.
methodsThe current study was conducted on 365 patients with chronic pain. The participants were evaluated on their stool form (the Bristol stool form scale; BSFS), constipation state (the Cleveland clinic constipation score; CCCS), body mass index (BMI), and usual pain severity (numerical rating scale; NRS). In addition, the participants were assigned into five groups according to the pain region (i e, low back and/or lower limb, whole body, neck and/or upper back and/or upper limb, head and/or face, chest and/or abdominal).
resultsThe CCS showed a significant and positive association with the pain severity of the total patients and patients with low back and/or lower limb pain. Simultaneous multiple linear regression analyses revealed that a predictor of the pain severity was the CCS for the total patients and patients with low back and/or lower limb, whole body pain.
conclusionsConstipation displayed a significant and positive association with the pain severity of the total patients and patients with low back and/or lower limb pain, whole body.
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