Evidence map›Paper›PMID 30250809›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream.

Veronica Iacovacci, Leonardo Ricotti, Edoardo Sinibaldi, Giovanni Signore, Fabio Vistoli, Arianna Menciassi

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Remotely Controlled 3D-Engineered Scaffolds for Biomimetic In Vitro Investigations on Brain Cell Cocultures.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. The State-of-the-Art and Perspectives of Laser Ablation for Tumor Treatment.Cyborg and bionic systems (Washington, D.C.) · 2024
    Article
  12. Article
  13. Magnetically steerable catheters: State of the art review.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Magnetic particle targeting for diagnosis and therapy of lung cancers.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veronica IacovacciThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà, 33 56127 Pisa PI Italy.ORCID 0000-0002-4052-3581
Leonardo RicottiThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà, 33 56127 Pisa PI Italy.
Edoardo SinibaldiCenter for Micro-BioRobotics @SSSA Istituto Italiano di Tecnologia Viale Rinaldo Piaggio 34 56025 Pontedera Italy.
Giovanni SignoreCenter of Nanotechnology Innovation@NEST Istituto Italiano di Tecnologia 56127 Pisa Italy.
Fabio VistoliDivision of General and Transplant Surgery Azienda Ospedaliera Universitaria PisanaUniversity of Pisa Via Paradisa 2 56124 Pisa Italy.
Arianna MenciassiThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà, 33 56127 Pisa PI Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical adoption of nanoscale agents for targeted therapy is still hampered by the quest for a balance between therapy efficacy and side effects on healthy tissues, due to nanoparticle biodistribution and undesired drug accumulation issues. Here, an intravascular catheter able to efficiently retrieve from the bloodstream magnetic nanocarriers not contributing to therapy, thus minimizing their uncontrollable dispersion and consequently attenuating possible side effects, is proposed. The device consists of a miniature module, based on 27 permanent magnets arranged in two coaxial series, integrated into a clinically used 12 French catheter. This device can capture ≈94% and 78% of the unused agents when using as carriers 500 and 250 nm nominal diameter superparamagnetic iron oxide nanoparticles, respectively. This approach paves the way to the exploitation of new "high-risk/high-gain" drug formulations and supports the development of novel therapeutic strategies based on magnetic hyperthermia or magnetic microrobots.

Indexed as

intravascular devicesmagnetic nanoparticlesmagnetic retrievaltargeted therapy

Identifiers

PMID30250809
PMCPMC6145422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.