ArticleFrontiers in zoology2018
Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees.
Article in Frontiers in zoology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Ageing processes in the bonobo gut microbiome mirror human patterns.NPJ biofilms and microbiomes · 2026Article
- Klotho in aging and diseases: molecular features, expressions, and functional implications.Molecular and cellular biochemistry · 2026Review
- Sex-specific association between serum α-klotho levels and sleep disturbances in the elderly: a cross-sectional study.European journal of medical research · 2025Article
- The association between the triglyceride-glucose index and serum anti-aging protein α- Klotho: a population-based study.Diabetology & metabolic syndrome · 2024Article
- The role of age and sex in non-linear dilution adjustment of spot urine arsenic.BMC nephrology · 2024Article
- Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.Communications biology · 2024Article
- Association between serum Klotho levels and hypothyroidism in older adults: NHANES 2007-2012.Scientific reports · 2024Article
- Sexually dimorphic renal expression ofResearch square · 2024Article
- Determination of the reference interval for urinary klotho to creatinine ratio of healthy dogs.Frontiers in veterinary science · 2024Article
- The fibroblast growth factor-Klotho axis at molecular level.Open life sciences · 2023Review
- Higher levels of serum α-Klotho are longitudinally associated with less central obesity in girls experiencing weight gain.Frontiers in endocrinology · 2023Article
- Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case-control study.Journal of endocrinological investigation · 2022Article
- References Values of Soluble α-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years.Journal of clinical medicine · 2022Article
- Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function.Journal of Alzheimer's disease : JAD · 2022Article
- Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals.Frontiers in cardiovascular medicine · 2022Article
- AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Klotho as Potential Autophagy Regulator and Therapeutic Target.Frontiers in pharmacology · 2021Review
- Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1Journal of molecular neuroscience : MN · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThroughout life, physiological homeostasis is challenged and the capacity to cope with such challenges declines with increasing age. In many species, sex differences exist in life expectancy. Sex-specific differences have been related to extrinsic factors like mate competition and/or intrinsic proximate mechanisms such as hormonal changes. In humans, an intrinsic factor related to aging is soluble alpha klotho (α-Kl). Both sexes show an age-related decline in α-Kl, but throughout life women have higher levels than men of the same age. Sex differences in α-Kl have been linked to a shorter lifespan, as well as to specific morbidity factors such as atherosclerosis and arteries calcifications. In non-human animals, information on α-Kl levels is rare and restricted to experimental work. Our cross-sectional study is the first on α-Kl levels in two long-lived species: bonobos (
methodsWe measured serum α-Kl levels of 140 subjects from 16 zoos with an ELISA to examine if α-Kl levels reflect this difference in life expectancy.
resultsIn both species and in both sexes, α-Kl levels declined with age suggesting that this marker has potential for aging studies beyond humans. We also found species-specific differences. Adult female bonobos had higher α-Kl levels than males, a difference that corresponds to the pattern found in humans. In chimpanzees, we found the opposite: males had higher α-Kl levels than females.
conclusionWe suggest that contrasting sex differences in adult α-Kl levels mirror the dominance relations between females and males of the two
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.