ArticleFrontiers in immunology2018
Increased Risk for Malignancies in 131 Affected
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-Analysis.Journal of clinical immunology · 2024Pooled it
- Immunogenetics of gastrointestinal cancers: A systematic review and retrospective survey of inborn errors of immunity in humans.Journal of gastroenterology and hepatology · 2022Pooled it
- Comprehensive comparison between 222 CTLA-4 haploinsufficiency and 212 LRBA deficiency patients: a systematic review.Clinical and experimental immunology · 2021Pooled it
- Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study.Frontiers in immunology · 2021Pooled it
- Article
- Multifocal HPV16-positive squamous cell carcinomas in CTLA-4 haploinsufficiency: expanding the spectrum of virus-associated malignancies.Immunologic research · 2026Article
- Regulation of immune checkpoint molecules in cancer immune evasion and therapy.Nature reviews. Cancer · 2026Review
- Clinical Spectrum and Therapeutic Options in Monogenic CTLA-4-, LRBA-, or SOCS1-Related Primary Immune Regulatory Disorders.The journal of allergy and clinical immunology. In practice · 2026Review
- Article
- CTLA-4 haploinsufficiency presenting with chronic myeloid leukemia, bullous pemphigoid, and PLA2R-positive membranous nephropathy: a case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Identification and verification of SPP1 in anoikis as a prognostic biomarker for intestinal metaplasia and gastric cancer.Scientific reports · 2026Article
- A New Variant in CTLA4 Highlights the Heterogeneous Phenotype of CTLA4 Haploinsufficiency.Journal of clinical immunology · 2025Article
- Tregopathy in focus.Frontiers in immunology · 2025Article
- Infections in Disorders of Immune Regulation.Pathogens (Basel, Switzerland) · 2024Review
- Functional genomics in inborn errors of immunity.Immunological reviews · 2024Review
- Case Report: Aplastic anemia related to a novelFrontiers in pediatrics · 2024Article
- The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency.Frontiers in immunology · 2024Article
- Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards.Nature reviews. Gastroenterology & hepatology · 2023Review
- Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry.Journal of clinical immunology · 2023Article
- Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation.Molecular and cellular pediatrics · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 16 institutions in 8 countries.
David EggFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
Charlotte SchwabFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
Annemarie GabryschFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
Peter D ArkwrightRoyal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom.
Edmund CheesmanRoyal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom.
Lisa Giulino-RothDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States.
Olaf NethSeccion de Infectologia e Inmunopatologia, Unidad de Pediatria, Hospital Virgen del Rocio/Instituto de Biomedicina de Sevilla, Sevilla, Spain.
Scott SnapperDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children's Hospital Boston, Boston, MA, United States.
Satoshi OkadaDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.
Michel MoutschenDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liege, Liege, Belgium.
Philippe DelvenneDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liege, Liege, Belgium.
Ann-Christin PecherDepartment of Internal Medicine II, University Hospital Tübingen, Tübingen, Germany.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Yae-Jean KimDivision of Infectious Diseases and Immunodeficiency, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Suranjith SeneviratneInstitute of Immunity and Transplantation, Royal Free Hospital, University College London, London, United Kingdom.
Kyoung-Mee KimDepartment of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Ji-Man KangNational Cancer Center, Goyang, South Korea.
Samar OjaimiDepartment of Paediatrics, Monash University, Clayton, VIC, Australia.
Catriona McLeanAlfred Health, Prahran, VIC, Australia.
Klaus WarnatzFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
Maximilian SeidlFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
Bodo GrimbacherFaculty of Medicine, Center for Chronic Immunodeficiency, Medical Center of the University Hospital, University of Freiburg, Freiburg, Germany.
University Medical Center Freiburg · DEUniversity of Freiburg · DEUniversity of Liège · BEUniversity of Manchester · GBAlfred Health · AUBoston Children's Hospital · USCornell University · USHiroshima University · JPInstituto de Biomedicina de Sevilla · ESMonash University · AUNational Cancer Center · KRSamsung Medical Center · KRSungkyunkwan University · KRUniversity Children's Hospital Tübingen · DEUniversity College London · GBUniversity Hospital Regensburg · DE
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JERROLD R. TURNER · 1986 to 2026
$32.4MRational Translation of EZH2 Targeted Therapy in Germinal Center B-cell LymphomaK08CA219473 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROTH, LISA GIULINO · 2017 to 2020
$684kNIDDK NIH HHS P30 DK034854
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdenocarcinomaAdolescentAdultAgedCohort StudiesCTLA-4 AntigenEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLymphomaMaleMiddle AgedMutationPrevalenceRiskCTLA-4 AntigenCTLA4 protein, humancancer predispositionCMVcombined immunodeficiencyCTLA4EBVmalignancyprimary immunodeficiency
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.