Evidence map›Paper›PMID 30250424›Full record

ArticleFrontiers in molecular neuroscience2018

A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention.

Elad Lax, Gal Warhaftig, David Ohana, Rachel Maayan, Yael Delayahu, Paola Roska, Alexander M Ponizovsky, Abraham Weizman, Gal Yadid, Moshe Szyf

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Elad LaxDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Gal WarhaftigThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
David OhanaMax Wertheimer Minerva Center for Cognitive Processes and Human Performance, Technion - Israel Institute of Technology, Haifa, Israel.
Rachel MaayanLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, Israel.
Yael DelayahuLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, Israel.
Paola RoskaDepartment for the Treatment of Substance Abuse and Mental Health Services, Israeli Ministry of Health, Jerusalem, Israel.
Alexander M PonizovskyDepartment for the Treatment of Substance Abuse and Mental Health Services, Israeli Ministry of Health, Jerusalem, Israel.
Abraham WeizmanLaboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit and Geha Mental Health Center, Tel Aviv University, Tel Aviv, Israel.
Gal YadidThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Moshe SzyfDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Bar-Ilan University · ILGeha Mental Health Center · ILMcGill University · CAHebrew University of Jerusalem · ILIsrael Ministry of Health · ILTechnion – Israel Institute of Technology · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (

Indexed as

dehydroepiandrosterone (DHEA)DNA methylationdrug abusedrug-addictiongenome-wide analysis

Identifiers

PMID30250424
PMCPMC6139343
OpenAlexW2891930259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.