Evidence map›Paper›PMID 30250289›Full record

ArticleNature protocols2018

Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the Al

Frederik Cleeren, Joan Lecina, Jessica Bridoux, Nick Devoogdt, Térence Tshibangu, Catarina Xavier, Guy Bormans

Abstract read
PubMed Publisher
In one paragraph

Article in Nature protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 68 citations in OpenAlex.

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  19. Arginine-Selective Bioconjugation Reagent for EffectiveJournal of medicinal chemistry · 2024
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  20. Radiosynthesis and preclinical evaluations of [American journal of nuclear medicine and molecular imaging · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frederik CleerenRadiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3692-1608
Joan LecinaRadiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium.
Jessica BridouxIn Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0002-8895-9763
Nick DevoogdtIn Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0001-9220-4833
Térence TshibanguRadiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium.
Catarina XavierIn Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium.
Guy BormansRadiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium. guy.bormans@kuleuven.be.
KU Leuven · BEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positron emission tomography (PET) is a quickly expanding, non-invasive molecular imaging technology, and there is high demand for new specific imaging probes. Herein, we present a generic protocol for direct radiolabeling of heat-sensitive biomolecules with the positron-emitting radioisotope fluorine-18 (

Indexed as

Aluminum CompoundsAnimalsCoordination ComplexesFluoridesFluorine RadioisotopesHeterocyclic CompoundsHot TemperatureMiceModels, MolecularPeptidesPositron-Emission TomographyProteinsRatsSingle-Domain AntibodiesTissue Distribution1,4,7-triazacyclononane-1,4-diacetateAluminum Compoundsaluminum fluorideCoordination ComplexesFluoridesFluorine-18Fluorine RadioisotopesHeterocyclic CompoundsPeptidesProteinsSingle-Domain Antibodies

Identifiers

PMID30250289
OpenAlexW2893188737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.