Evidence map›Paper›PMID 30250263›Full record

ArticleNature neuroscience2018

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.

Anubhuti Goel, Daniel A Cantu, Janna Guilfoyle, Gunvant R Chaudhari, Aditi Newadkar, Barbara Todisco, Diego de Alba, Nazim Kourdougli, Lauren M Schmitt, Ernest Pedapati and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 188 citations in OpenAlex.

  1. Article
  2. Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit.Autism research : official journal of the International Society for Autism Research · 2026
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  11. Review
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  13. Degraded sensory coding in a mouse model ofbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Learning impairments in Fmr1Journal of neurodevelopmental disorders · 2025
    Article
  18. Article
  19. Atypical Retinal Ganglion Cell Function in a Mouse Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anubhuti GoelDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Daniel A CantuDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Janna GuilfoyleDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Gunvant R ChaudhariDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Aditi NewadkarDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Barbara TodiscoDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Diego de AlbaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Nazim KourdougliDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Lauren M SchmittDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ernest PedapatiDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Craig A EricksonDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Carlos Portera-CailliauDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. cpcailliau@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-5735-6380
University of California, Los Angeles · USCincinnati Children's Hospital Medical Center · US

Funding

Neurophysiological and acute pharmacological studies in FXS patientsU54HD082008 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI HUBER, KIMBERLY M. · 2014 to 2019
$9.8M
Imaging the origin of dendritic spine abnormalities in fragile X miceR01HD054453 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Carlos Portera-Cailliau · 2007 to 2026
$6.5M
Anomalous Sensorimotor Physiology in Fragile X SyndromeK23MH112936 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI PEDAPATI, ERNEST VIJAY · 2017 to 2021
$916k
Using Longitudinal Data to Characterize the Natural History of Fragile X Syndrome (FXS) to Improve Services and Outcomes-Component CU01DD001185 · DD · CINCINNATI CHILDRENS HOSP MED CTR · PI ERICKSON, CRAIG · 2016 to 2019
$400k
ACL HHS U01DD001185NCBDD CDC HHS U01 DD001185NICHD NIH HHS R01 HD054453NICHD NIH HHS U54 HD082008NIMH NIH HHS K23 MH112936
6 · The paper itself

Abstract

To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1

Indexed as

AdolescentAdultAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Choice BehaviorDiscrimination, PsychologicalDisease Models, AnimalFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansInhibition, PsychologicalLearning DisabilitiesMaleMiceMice, TransgenicCalcium-Calmodulin-Dependent Protein Kinase Type 2Fmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1OxygenParvalbuminsReceptors, G-Protein-Coupled

Identifiers

PMID30250263
PMCPMC6161491
OpenAlexW2891354340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.