Evidence map›Paper›PMID 30250232›Full record

ArticleScientific reports2018

Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients.

Yan Zhao, Bin Chen, Shufeng Li, Lanxiu Yang, Dequan Zhu, Ye Wang, Haiying Wang, Tao Wang, Bin Shi, Zhongtao Gai and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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  19. Microbial threads in the tapestry of rheumatoid arthritis.The Journal of clinical investigation · 2025
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Yan ZhaoCollege of Life Science, Shandong Normal University, Jinan, 250014, China.
Bin ChenCollege of Life Science, Shandong Normal University, Jinan, 250014, China.
Shufeng LiDepartment of Orthopedics, Qianfoshan Hospital Affiliated to Shandong University, Jinan, 250014, China.
Lanxiu YangGuoyitang Hospital, Jinan, 250000, China.
Dequan ZhuMicrobiological Laboratory, Linyi People's Hospital, Linyi, 276003, China.
Ye WangQingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao, 266000, China.
Haiying WangCollege of Life Science, Shandong Normal University, Jinan, 250014, China.
Tao WangShandong Medicinal and Biotechnology Centre, Shandong Academy of Medical Sciences, Jinan, 250062, China.
Bin ShiShandong Medicinal and Biotechnology Centre, Shandong Academy of Medical Sciences, Jinan, 250062, China.
Zhongtao GaiShandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan, 250001, China.
Jun YangBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing, 100191, China.
Xueyuan HengMicrobiological Laboratory, Linyi People's Hospital, Linyi, 276003, China. xueyuanheng@yahoo.com.
Junjie YangCollege of Life Science, Shandong Normal University, Jinan, 250014, China. microbiota@foxmail.com.
Lei ZhangCollege of Life Science, Shandong Normal University, Jinan, 250014, China. microbiome@foxmail.com.
Linyi People's Hospital · CNShandong First Medical University · CNQilu Normal University · CNShandong Normal University · CNAffiliated Hospital of Qingdao University · CNQilu Hospital of Shandong University · CNShandong University · CNTang Hospital · CN

Funding

Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 31471202Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2014YL040
6 · The paper itself

Abstract

Human intestinal microbes can mediate development of arthritis - Studies indicate that certain bacterial nucleic acids may exist in synovial fluid (SF) and could be involved in arthritis, although the underlying mechanism remains unclear. To characterize potential SF bacterial nucleic acids, we used 16S rRNA gene amplicon sequencing to assess bacterial nucleic acid communities in 15 synovial tissue (ST) and 110 SF samples from 125 patients with rheumatoid arthritis (RA) and 16 ST and 42 SF samples from 58 patients with osteoarthritis (OA). Our results showed an abundant diversity of bacterial nucleic acids in these clinical samples, including presence of Porphyromonas and Bacteroides in all 183 samples. Agrobacterium, Comamonas, Kocuria, Meiothermus, and Rhodoplanes were more abundant in synovial tissues of rheumatoid arthritis (STRA). Atopobium, Phascolarctobacterium, Rhodotorula mucilaginosa, Bacteroides uniformis, Rothia, Megasphaera, Turicibacter, Leptotrichia, Haemophilus parainfluenzae, Bacteroides fragilis, Porphyromonas, and Streptococcus were more abundant in synovial tissues of osteoarthritis (STOA). Veillonella dispar, Haemophilus parainfluenzae, Prevotella copri and Treponema amylovorum were more abundant in synovial fluid of rheumatoid arthritis (SFRA), while Bacteroides caccae was more abundant in the synovial fluid of osteoarthritis (SFOA). Overall, this study confirms existence of bacterial nucleic acids in SF and ST samples of RA and OA lesions and reveals potential correlations with degree of disease.

Indexed as

AdultAlgorithmsArthritis, RheumatoidBacteriaCytokinesDiscriminant AnalysisHumansMicrobiotaNucleic AcidsOsteoarthritisPrincipal Component AnalysisSynovial FluidSynovial MembraneCytokinesNucleic Acids

Identifiers

PMID30250232
PMCPMC6155189
OpenAlexW2889967749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.