ArticleScientific reports2018
Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Effect of Probiotics on the Gut-Mammary Pathway: Implications on Infant Microbiota Transfer and Development.Current nutrition reports · 2026Review
- "Breast is Best": does this also apply to neonatal neuroprotection?Pediatric research · 2026Article
- Human milk: insights on cell composition, organoids and emerging applications.Pediatric research · 2026Review
- Functional shifts in immune composition follow lactation stage in human milk.Frontiers in immunology · 2026Article
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Breast milk stem cells integrate into cellular remodeling and functional differentiation in the ischemic brain.Scientific reports · 2025Article
- Equine Colostrum-Derived Mesenchymal Stromal Cells: A Potential Resource for Veterinary Regenerative Medicine.Veterinary sciences · 2025Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Effects and mechanisms of breastmilk stem cells in the treatment of white matter injury in newborn rats.Stem cell research & therapy · 2025Article
- Challenges and Opportunities in Quantifying Bioactive Compounds in Human Breastmilk.Biomolecules · 2025Review
- Outcomes after intranasal human milk therapy in preterm infants with intraventricular hemorrhage.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Breast Milk Stem Cells in the Treatment of Neonatal Diseases.Current stem cell research & therapy · 2025Review
- Maternal immune activation does not affect maternal microchimeric cells.Biology open · 2024Article
- Feasibility of intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Human breast tissue engineering in health and disease.EMBO molecular medicine · 2024Review
- Article
- Infant respiratory infections modulate lymphocyte homing to breast milk.Frontiers in immunology · 2024Article
- Where does the time go? Temporal patterns of pumping behaviors in mothers of very preterm infants vary by sociodemographic and clinical factors.Frontiers in nutrition · 2024Article
- Breastfeeding-Related Health Benefits in Children and Mothers: Vital Organs Perspective.Medicina (Kaunas, Lithuania) · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal cells in the suckling's blood and the brain. Green fluorescent protein expressing transgenic female mice (GFP+) were used as foster mothers to breastfeed wildtype newborn pups. One week and two months after the birth, blood samples and brains of the sucklings were analyzed to detect presence of GFP+ cells by fluorescence activated cell sorting, polymerase chain reaction and immunohistochemistry on the brain sections and optically cleared brains. The tests confirmed that maternal cells were detectable in the blood and the brain of the pups and that they differentiated into both neuronal and glial cell types in the brain. This phenomenon represents breastfeeding - induced microchimerism in the brain with functional implications remain to be understood.
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