ArticleNature medicine2018
Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.
Erratum issued 6 registry-linked trialsAbstract read
In one paragraph
Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 6 registered trials, which are not on this map. Cited by 313 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed, 3 pooled it
39.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Feasibility Study: Epidural Stimulation to Enable Volitional Movement After Chronic Complete Paralysis in Humans.
Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury
Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury: an Interventional, Prospective, Monocentric Study
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI
Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function in Non-traumatic Spinal Cord Injury: an Interventional, Prospective, Monocentric Study
Who cites it
313 citing papers in PubMed, 3 syntheses or guidelines pooled it, 561 citations in OpenAlex.
- Clinical applications of invasive spinal cord stimulation in neurological disorders: a narrative review.Frontiers in neurology · 2026Pooled it
- Global research trends and hotspots of artificial intelligence research in spinal cord neural injury and restoration-a bibliometrics and visualization analysis.Frontiers in neurology · 2024Pooled it
- Transcutaneous spinal cord stimulation effects on spasticity in patients with spinal cord injury: A systematic review.The journal of spinal cord medicine · 2023Pooled it
- Postural changes and motor evoked potentials following percutaneous spinal cord epidural stimulation in spinal cord injury.Spinal cord series and cases · 2026Trial
- Effect of Cervical Epidural STimulation After Neurological Damage: protocol for phase I/II open label controlled CE-STAND trial.BMJ open · 2026Trial
- Activity-based recovery training with spinal cord epidural stimulation improves standing performance in cervical spinal cord injury.Journal of neuroengineering and rehabilitation · 2025Trial
- First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy.Nature medicine · 2025Trial
- Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.Nature medicine · 2024Trial
- Trial
- Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury.Annals of neurology · 2023Trial
- Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.Nature medicine · 2022Trial
- Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes.Journal of clinical medicine · 2026Article
- From Trial to Chronic Epidural Electrical Stimulation: A Single-Patient Feasibility Study in Motor-Complete Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Off-target effects of percutaneous epidural spinal cord and dorsal root ganglion stimulation with task-specific training on lower urinary tract function in individuals with chronic spinal cord injury.The journal of spinal cord medicine · 2026Article
- Article
- Spinal cord tissueoid transplantation combined with tail nerve electrical stimulation promotes the voluntary movement of paralyzed hindlimbs in rats with transected spinal cord injury.Materials today. Bio · 2026Article
- Bypass neural interfaces for paralysis: clinical translation, challenges and future directions.Journal of neuroengineering and rehabilitation · 2026Review
- Sensor Inputs and Closed-Loop Neuromodulation in Spinal Cord Injury: From Animal Models to Clinical Translation.Sensors (Basel, Switzerland) · 2026Review
- Spinal epidural electrical stimulation for the recovery of motor function in lower limbs after spinal cord injury: A pilot study.The journal of spinal cord medicine · 2026Article
- Transcutaneous spinal stimulation with upper extremity robotic training in chronic stroke and spinal cord injury: individual neurophysiological and clinical responses.Journal of neuroengineering and rehabilitation · 2026Article
253 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
17 authors at 4 institutions in 2 countries.
Megan L GillRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Peter J GrahnDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Jonathan S CalvertMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7197-9082
Margaux B LindeRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Igor A LavrovDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Jeffrey A StrommenRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Lisa A BeckRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Dimitry G SayenkoDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Meegan G Van StraatenRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Dina I DrubachDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Daniel D VeithRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Andrew R ThoresonRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Cesar LopezRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Yury P GerasimenkoDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
V Reggie EdgertonDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Kendall H LeeRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. lee.kendall@mayo.edu.
Kristin D ZhaoRehabilitation Medicine Research Center, Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. zhao.kristin@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USUniversity of California, Los Angeles · USHouston Methodist · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis
Indexed as
Transcutaneous Electric Nerve StimulationAdultElectric StimulationElectromyographyHumansMaleMotor ActivityMuscle, SkeletalNerve NetParalysisParaplegiaSpinal Cord Injuries
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02592668ClinicalTrials.gov
NCT04965727ClinicalTrials.gov
NCT05926843ClinicalTrials.gov
NCT06213012ClinicalTrials.gov
NCT07375745ClinicalTrials.gov
NCT07412808ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.