ReviewMaterials (Basel, Switzerland)2018
A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes.
Review in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- BMP-2 in oral-maxillofacial bone augmentation: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Bioactive inorganic materials in dental resin infiltrants: a systematic and critical review of their effects on infiltrant properties and tooth surfaces.Clinical oral investigations · 2025Pooled it
- Progress in Hydroxyapatite Nanocarriers for Targeted and Enhanced Osteoporosis Treatment: A Comprehensive Review.Molecular biotechnology · 2026Review
- Bamboo-Like Whiskers-Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type-H Vessels and Osteoinduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 3D-Printed Bone Spacers with Dual-Phase Structure: A Comparison of Biogenic and Commercial Hydroxyapatite for Potential Treatment of Bone Defects.ACS applied bio materials · 2026Article
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
- Synergistic Effect of Poly(ethylenephosphoric Acid) and Cerium in Bone Substitute Composites on Tissue Response and Bone Remodeling.International journal of molecular sciences · 2025Article
- Polyetheretherketone for craniomaxillofacial defects: cases report, evaluation of patients' satisfaction and a systematic literature review.Maxillofacial plastic and reconstructive surgery · 2025Article
- Novel Applications of Natural Biomaterials in Dentistry-Properties, Uses, and Development Perspectives.Materials (Basel, Switzerland) · 2025Review
- Bone Defect Treatment in Regenerative Medicine: Exploring Natural and Synthetic Bone Substitutes.International journal of molecular sciences · 2025Review
- Bone Regeneration: A Review of Current Treatment Strategies.Journal of clinical medicine · 2025Review
- Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies.Biomacromolecules · 2025Review
- An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology.Materials (Basel, Switzerland) · 2024Review
- Dental Applications of Ion-Substituted Hydroxyapatite: A Review of the Literature.Dentistry journal · 2024Review
- Polysaccharide Hydroxyapatite (Nano)composites and Their Biomedical Applications: An Overview of Recent Years.ACS omega · 2024Review
- Effects of bone surface topography and chemistry on macrophage polarization.Scientific reports · 2024Article
- Electrophoretic Deposition of Calcium Phosphates on Carbon-Carbon Composite Implants: Morphology, Phase/Chemical Composition and Biological Reactions.International journal of molecular sciences · 2024Article
- Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction.Biomimetics (Basel, Switzerland) · 2024Review
- Graphene: A Multifaceted Carbon-Based Material for Bone Tissue Engineering Applications.ACS omega · 2024Review
- The Association of Nanostructured Carbonated Hydroxyapatite with Denatured Albumin and Platelet-Rich Fibrin: Impacts on Growth Factors Release and Osteoblast Behavior.Journal of functional biomaterials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomedical materials constitute a vast scientific research field, which is devoted to producing medical devices which aid in enhancing human life. In this field, there is an enormous demand for long-lasting implants and bone substitutes that avoid rejection issues whilst providing favourable bioactivity, osteoconductivity and robust mechanical properties. Hydroxyapatite (HAp)-based biomaterials possess a close chemical resemblance to the mineral phase of bone, which give rise to their excellent biocompatibility, so allowing for them to serve the purpose of a bone-substituting and osteoconductive scaffold. The biodegradability of HAp is low (Ksp ≈ 6.62 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.