Evidence map›Paper›PMID 30249874›Full record

ArticleJournal of cancer research and therapeutics2018

Deglycosylation of wogonoside enhances its anticancer potential.

Chong-Zhi Wang, Jin-Yi Wan, Chun-Feng Zhang, Fang Lu, Lina Chen, Chun-Su Yuan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Therapeutic Potential of Bioactive Components fromInternational journal of molecular sciences · 2023
    Review
  2. Review
  3. International journal of environmental research and public health · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Chong-Zhi WangTang Center for Herbal Medicine Research, University of Chicago; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.
Jin-Yi WanTang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA; Department of Traditional Chinese Medicine and Pharmaceutical Sciences, School of Pharmacy, Jiangsu University, Zhenjiang, JS 212013, China.
Chun-Feng ZhangTang Center for Herbal Medicine Research, University of Chicago; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.
Fang LuTang Center for Herbal Medicine Research, University of Chicago; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.
Lina ChenTang Center for Herbal Medicine Research, University of Chicago; Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.
Chun-Su YuanTang Center for Herbal Medicine Research, University of Chicago; Department of Anesthesia and Critical Care, University of Chicago; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA.
University of Chicago · US

Funding

Center for Herbal Research on Colorectal CancerP01AT004418 · NCCIH · UNIVERSITY OF CHICAGO · PI YUAN, CHUN-SU · 2008 to 2012
$5.9M
Chemoprevention of Active Scutellaria baicalensis Fraction on Colon CancerK01AT005362 · NCCIH · UNIVERSITY OF CHICAGO · PI WANG, CHONG-ZHI · 2010 to 2014
$486k
NCCIH NIH HHS K01 AT005362NCCIH NIH HHS P01 AT004418
6 · The paper itself

Abstract

introductionScutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of S. baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism. MATERIALS AND

methodsThe antiproliferative effects of the glycoside (wogonoside) and its deglycosylated compound (wogonin) on a panel of human cancer cell lines from the most common solid tumors were evaluated using the MTS colorimetric assay. Cell cycle and apoptosis were determined using flow cytometry. Enzymatic activities of caspases were measured, and the interactions of wogonin and caspases were explored by a docking analysis.

resultsWogonoside did not have obvious antiproliferative effects on the cancer cells. In contrast, wogonin showed significant antiproliferative activities on all the tested cancer cells. Wogonin arrested the cells in the G1 phase and significantly induced cell apoptosis. The compound also activated the expression of caspases 3 and 9. The docking results suggest that the compound forms hydrogen bonds with Phe250 and Ser251, and π-π interactions with Phe256 in caspase 3, and with Asp228 in caspase 9.

conclusionsAfter wogonoside deglycosylation, wogonin significantly enhanced its anticancer potential as a potent anticancer compound derived from S. baicalensis.

Indexed as

ApoptosisCaspase 3Caspase 9Cell Line, TumorCell ProliferationFlavanonesFlow CytometryGene Expression Regulation, NeoplasticGlucosidesGlycosylationHumansHydrogen BondingMCF-7 CellsMicrobiotaMolecular Docking SimulationNeoplasmsCaspase 3Caspase 9FlavanonesGlucosidesPlant ExtractsScutellaria baicalensis extractwogoninwogonosideApoptosisdeglycosylationreceptor-ligand dockingwogoninwogonoside

Identifiers

PMID30249874
PMCPMC6159225
OpenAlexW2883183645

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.