ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Strategies for Optimizing Genetic Mouse Models to Enhance the Understanding of Parkinson's Disease.Biomedicines · 2026Review
- Parkinson's disease and the concept of resilience, cognitive, and motor reserve.Journal of Parkinson's disease · 2026Review
- Synergistic Effects of Multi-Kinase Inhibition onBiomedicines · 2026Article
- Parkinson's Disease Patient-Specific Striatum Organoids Show Hallmarks of Increased Inflammation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Plasma Levels of Food-Derived Metabolites as Biomarkers of Parkinson's Disease.International journal of molecular sciences · 2025Article
- LRRK2 and the fragile synapse: a molecular prelude to Parkinson's disease?The Biochemical journal · 2025Review
- LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons.Molecular psychiatry · 2025Article
- PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.bioRxiv : the preprint server for biology · 2025Article
- Affective phenotypes in heterozygousFrontiers in genetics · 2025Article
- The senescent synapse: A look at autophagy, calcium handling, and mitochondrial bioenergetics at the synapse in ageing and Parkinson's disease.Current research in physiology · 2025Review
- Multi-method computational evaluation of the inhibitors against leucine-rich repeat kinase 2 G2019S mutant for Parkinson's disease.Molecular diversity · 2024Article
- Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Parkinson's LRRK2-G2019S risk gene mutation drives sex-specific behavioral and cellular adaptations to chronic variable stress.Frontiers in behavioral neuroscience · 2024Article
- Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation.Frontiers in cellular neuroscience · 2024Article
- Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.International journal of molecular sciences · 2023Review
- Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.Acta neuropathologica communications · 2023Article
- Caffeine intake interacts with Asian gene variants in Parkinson's disease: a study in 4488 subjects.The Lancet regional health. Western Pacific · 2023Article
- Modeling Parkinson's disease in LRRK2 rodents.Neuronal signaling · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Bridget A Matikainen-AnkneyDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Nebojsa KezunovicDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Caroline MenardDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0001-8202-7378
Meghan E FlaniganDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0002-3185-7459
Yue ZhongDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Scott J RussoDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0002-6470-1805
Deanna L BensonDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029 george.huntley@mssm.edu deanna.benson@mssm.edu.ORCID 0000-0001-7037-1147
George W HuntleyDepartment of Neuroscience, Friedman Brain Institute, and the Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029 george.huntley@mssm.edu deanna.benson@mssm.edu.ORCID 0000-0003-3645-6192
Allen Institute for Brain Science · US
Funding
Developmentally sensitive regulatory mechanisms of synapse assembly and functionR01MH103455 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, GUNAL, OZLEM · 2014 to 2018
$2.1MCdh8-dependent circuit development in autismR01MH104491 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2016 to 2020
$1.9MSusceptibility to depression by human disease-causing mutationR21MH110727 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HUNTLEY, GEORGE W. · 2017 to 2018
$466kThe effect of PD-linked LRRK2 mutations on corticostriatal circuitsF31NS096892 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MATIKAINEN-ANKNEY, BRIDGET · 2016 to 2016
$39kNIMH NIH HHS R01 MH103455NIMH NIH HHS R01 MH104491NIMH NIH HHS R21 MH110727NINDS NIH HHS F31 NS096892
Abstract
The G2019S mutation in leucine-rich repeat kinase 2 (
Indexed as
Interpersonal RelationsResilience, PsychologicalAge FactorsAnimalsExcitatory Postsynaptic PotentialsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiceMice, Inbred C57BLMice, TransgenicMutationNeuronal PlasticityParkinson DiseaseStress, PsychologicalLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mousechronic social defeat stressLRRK2LTPnucleus accumbensresiliencestriatum
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.