ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Pathway-Specific Asymmetries between ON and OFF Visual Signals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Temporal prediction captures retinal spiking responses across animal species.Nature communications · 2026Article
- Projection targeting with phototagging to study the structure and function of retinal ganglion cells.Cell reports methods · 2026Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
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- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
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- Article
- Altered Functional Responses of the Retina in B6 Albino Tyrc/c Mice.Investigative ophthalmology & visual science · 2024Article
- Visual evoked potentials in patients with congenital color vision deficiency.International ophthalmology · 2024Article
- Asymmetries between achromatic increments and decrements: Perceptual scales and discrimination thresholds.Journal of vision · 2024Article
- GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Population encoding of stimulus features along the visual hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Population encoding of stimulus features along the visual hierarchy.bioRxiv : the preprint server for biology · 2023Article
- ON and OFF receptive field processing in the presence of optical scattering.Biomedical optics express · 2023Article
- Large-scale interrogation of retinal cell functions by 1-photon light-sheet microscopy.Cell reports methods · 2023Article
- Luminance Contrast Shifts Dominance Balance between ON and OFF Pathways in Human Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Efficient coding, channel capacity, and the emergence of retinal mosaics.Advances in neural information processing systems · 2022Article
- Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
Visual processing is largely organized into ON and OFF pathways that signal stimulus increments and decrements, respectively. These pathways exhibit natural pairings based on morphological and physiological similarities, such as ON and OFF α-ganglion cells in the mammalian retina. Several studies have noted asymmetries in the properties of ON and OFF pathways. For example, the spatial receptive fields (RFs) of OFF α-cells are systematically smaller than ON α-cells. Analysis of natural scenes suggests that these asymmetries are optimal for visual encoding. To test the generality of ON/OFF asymmetries, we measured the spatiotemporal RF properties of multiple RGC types in rat retina. Through a quantitative and serial classification, we identified three functional pairs of ON and OFF RGCs. We analyzed the structure of their RFs and compared spatial integration, temporal integration, and gain across ON and OFF pairs. Similar to previous results from the cat and primate, RGC types with larger spatial RFs exhibited briefer temporal integration and higher gain. However, each pair of ON and OFF RGC types exhibited distinct asymmetric relationships between RF properties, some of which were opposite to the findings of previous reports. These results reveal the functional organization of six RGC types in the rodent retina and indicate that ON/OFF asymmetries are pathway specific.
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