Evidence map›Paper›PMID 30249748›Full record

ArticleInfection and immunity2018

Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity.

Ellen E Higginson, Girish Ramachandran, Aruna Panda, Steven T Shipley, Edwin H Kriel, Louis J DeTolla, Michael Lipsky, Darren J Perkins, Rosangela Salerno-Goncalves, Marcelo B Sztein and 3 more

Abstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Developing Antiviral Vaccines Based on AttenuatedPathogens (Basel, Switzerland) · 2026
    Review
  2. Deletion of an immune evasion gene,Frontiers in immunology · 2024
    Article
  3. Article
  4. Reduced immunogenicity of a liveFrontiers in immunology · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ellen E HigginsonCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Girish RamachandranCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Aruna PandaProgram of Comparative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Steven T ShipleyProgram of Comparative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Edwin H KrielProgram of Comparative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Louis J DeTollaDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Michael LipskyDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Darren J PerkinsDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Rosangela Salerno-GoncalvesCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marcela F PasettiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Myron M LevineCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sharon M TennantCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA stennant@som.umaryland.edu.

Funding

Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GREENWALD, BRUCE D · 2009 to 2018
$27.8M
Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI109776
6 · The paper itself

Abstract

A notable proportion of

Indexed as

Immunogenicity, VaccineAnimalsAntibodies, BacterialBacterial ProteinsCytokinesDisease Models, AnimalFemaleGene DeletionHumansInflammationIntestinal MucosaMiceMice, Inbred BALB CMutationOrganoidsRabbitsAntibodies, BacterialBacterial ProteinsCytokinesSalmonella VaccinesVaccines, Attenuatedgastroenteritislive-attenuatedoral vaccinesSalmonella Typhimurium

Identifiers

PMID30249748
PMCPMC6246900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.