Evidence map›Paper›PMID 30249726›Full record

ArticleBMJ case reports2018

Mast cell deposition and activation may be a new explanation for epiploic appendagitis.

Leonard B Weinstock, Zahid Kaleem, Dale Selby, Lawrence B Afrin

Open access · hybridAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Leonard B WeinstockGastroenterology, GI, Washington University, Saint Louis, Missouri, USA.ORCID http://orcid.org/0000-0001-6484-1691
Zahid KaleemGastroenterology, GI, Washington University, Saint Louis, Missouri, USA.
Dale SelbyDepartment of Pathology, Missouri Baptist Medical Center, Saint Louis, Missouri, USA.
Lawrence B AfrinInternal Medicine, Armonk Integrative Medicine, Armonk, New York, USA.
Washington University in St. Louis · USARMGO Pharma (United States) · USMissouri Baptist Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epiploic appendagitis is as an acute painful condition of the fat on the outside of the intestine. Thus far, there have been no publications to our knowledge that appendagitis can be caused by mast cells or can be associated with chronic pain. A patient with multisystemic disorders suffered with both chronic and acute attacks of abdominal pain for a year. The worst attack led to surgical resection of an enlarged sigmoid colon epiploic appendage. Careful review of her complex medical history and mast cell stains of gastrointestinal biopsies led to the diagnosis of mast cell activation syndrome. Re-examination of the resected appendage using an immunohistochemical stain demonstrated a high mast cell density which is a new histopathological finding. Treatment of mast cell activation syndrome and other related syndromes led to marked improvement in her health, including all types of chronic abdominal pain.

Indexed as

Abdomen, AcuteAbdominal PainAdultChronic PainFemaleHumansMast CellsMastocytosisSigmoid Diseasesgastroenterologypain

Identifiers

PMID30249726
PMCPMC6157556
OpenAlexW2893348950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.