Evidence map›Paper›PMID 30249700›Full record

ArticleAntimicrobial agents and chemotherapy2018

The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model.

G L Drusano, M N Neely, W M Yamada, Brandon Duncanson, David Brown, Michael Maynard, Michael Vicchiarelli, Arnold Louie

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Analyzing Pharmacodynamic Count Data That Rapidly Decrease to Zero.CPT: pharmacometrics & systems pharmacology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Intravenous Fosfomycin for Systemic Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2023
    Review
  12. New and Repurposed Drugs for the Treatment of Active Tuberculosis: An Update for Clinicians.Respiration; international review of thoracic diseases · 2023
    Review
  13. Article
  14. Article
  15. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

G L DrusanoInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA gdrusano@ufl.edu.
M N NeelyChildren's Hospital of Los Angeles, Department of Pediatrics, Division of Infectious Diseases, University of Southern California, Los Angeles, California, USA.
W M YamadaChildren's Hospital of Los Angeles, Department of Pediatrics, Division of Infectious Diseases, University of Southern California, Los Angeles, California, USA.
Brandon DuncansonInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
David BrownInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Michael MaynardInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Michael VicchiarelliInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Arnold LouieInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Institute for Learning Innovation · USUniversity of Florida · USChildren's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Rapid Identification of Optimal Combination Regimens for Pseudomonas aeruginosaR01AI121430 · NIAID · UNIVERSITY OF FLORIDA · PI DRUSANO, GEORGE LOUIS, LOUIE, ARNOLD · 2016 to 2020
$4.1M
NIAID NIH HHS R01 AI121430
6 · The paper itself

Abstract

Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem.

Indexed as

Models, BiologicalAnti-Bacterial AgentsColony Count, MicrobialCulture MediaDiffusion Chambers, CultureDose-Response Relationship, DrugDrug CombinationsDrug Dosage CalculationsDrug Resistance, BacterialDrug SynergismFactor Analysis, StatisticalFosfomycinHumansMeropenemMetabolic Networks and PathwaysMicrobial Sensitivity TestsAnti-Bacterial AgentsCulture MediaDrug CombinationsFosfomycinMeropenemfosfomycinmeropenempharmacodynamicsPseudomonas aeruginosa

Identifiers

PMID30249700
PMCPMC6256766
OpenAlexW2892490545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.