Evidence map›Paper›PMID 30249687›Full record

ArticleAntimicrobial agents and chemotherapy2018

Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.

Liezl Gibhard, Mathew Njoroge, Tanya Paquet, Christel Brunschwig, Dale Taylor, Nina Lawrence, Efrem Abay, Sergio Wittlin, Lubbe Wiesner, Leslie J Street and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Dose-fractionation studies of aAntimicrobial agents and chemotherapy · 2024
    Article
  4. Update and elucidation ofComputational and structural biotechnology journal · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Liezl Gibhard *Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.ORCID 0000-0003-0089-2136
Mathew Njoroge *Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
Tanya PaquetDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Christel BrunschwigDrug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
Dale TaylorDrug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
Nina LawrenceDrug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
Efrem AbayDrug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
Sergio WittlinSwiss Tropical and Public Health Institute, Basel, Switzerland.
Lubbe WiesnerDepartment of Medicine, Division of Clinical Pharmacology, University of Cape Town, Observatory, South Africa.
Leslie J StreetDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Kelly ChibaleDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Gregory S BasarabDrug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa greg.basarab@uct.ac.za.
University of Cape Town · ZASouth African Medical Research Council · ZASwiss Tropical and Public Health Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

1-Phosphatidylinositol 4-KinaseAnimalsAntimalarialsBiotransformationDisease Models, AnimalDose-Response Relationship, DrugErythrocytesGene ExpressionHumansMalaria, FalciparumMaleMiceMice, Inbred NODMice, SCIDParasitemiaPlasmodium falciparum1-Phosphatidylinositol 4-KinaseAntimalarialsProdrugsPyrazinesSulfonesSulfoxidesmalariaNSG mouse modelprodrugsulfoxide

Identifiers

PMID30249687
PMCPMC6256810
OpenAlexW2900975211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.