Evidence map›Paper›PMID 30249661›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.

Leslie W Glustrom, Kenneth R Lyon, Margherita Paschini, Cynthia M Reyes, Nicholas V Parsonnet, Tasha B Toro, Victoria Lundblad, Deborah S Wuttke

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A comprehensive map of hotspots of de novo telomere addition inbioRxiv : the preprint server for biology · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Leslie W GlustromDepartment of Biochemistry, University of Colorado, Boulder, CO 80309.
Kenneth R LyonDepartment of Biochemistry, University of Colorado, Boulder, CO 80309.
Margherita PaschiniSalk Institute for Biological Studies, La Jolla, CA 92037.
Cynthia M ReyesSalk Institute for Biological Studies, La Jolla, CA 92037.
Nicholas V ParsonnetDepartment of Biochemistry, University of Colorado, Boulder, CO 80309.
Tasha B ToroSalk Institute for Biological Studies, La Jolla, CA 92037.
Victoria LundbladSalk Institute for Biological Studies, La Jolla, CA 92037.
Deborah S WuttkeDepartment of Biochemistry, University of Colorado, Boulder, CO 80309; Deborah.Wuttke@colorado.edu.
University of Colorado Boulder · USSalk Institute for Biological Studies · USUniversity of California, San Diego · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
SINGLE STRANDED DNA RECOGNITION IN TELOMERESR01GM059414 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI WUTTKE, DEBORAH S. · 1999 to 2015
$3.7M
Regulation of telomere homeostasis by replication fork progressionR01GM106060 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LUNDBLAD, VICTORIA · 2013 to 2016
$1.5M
NCI NIH HHS P30 CA014195NIGMS NIH HHS R01 GM059414NIGMS NIH HHS R01 GM106060NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

ssDNA, which is involved in numerous aspects of chromosome biology, is managed by a suite of proteins with tailored activities. The majority of these proteins bind ssDNA indiscriminately, exhibiting little apparent sequence preference. However, there are several notable exceptions, including the

Indexed as

Binding SitesDNA, Single-StrandedMutagenesis, Site-DirectedMutationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomereTelomere-Binding ProteinsCdc13 protein, S cerevisiaeDNA, Single-StrandedSaccharomyces cerevisiae ProteinsTelomere-Binding ProteinsCdc13DNA-binding specificitysingle-stranded DNA bindingtelomere maintenancet-RPA

Identifiers

PMID30249661
PMCPMC6187146
OpenAlexW2891315832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.