ArticleProceedings of the National Academy of Sciences of the United States of America2018
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Design and evolution of the tetracycline repressor into sulfonylurea herbicide-responsive gene switches for field crops.Nature communications · 2026Article
- An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.ACS central science · 2026Article
- The effects and potential mechanisms of statins on growth, development and pathogenicity in Botrytis cinerea.World journal of microbiology & biotechnology · 2025Article
- A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases.The Journal of antibiotics · 2025Article
- An easy and sensitive assay for acetohydroxyacid synthases based on the simultaneous detection of substrates and products in a single step.Analytical and bioanalytical chemistry · 2024Article
- The antioxidant and antimicrobial activity of ethanolic extract in roots, stems, and leaves of three commercial Cymbopogon species.BMC complementary medicine and therapies · 2024Article
- Flucofuron as a Promising Therapeutic Agent against Brain-Eating Amoeba.ACS infectious diseases · 2024Article
- The ilv2 gene, encoding acetolactate synthase for branched chain amino acid biosynthesis, is required for plant pathogenicity by Leptosphaeria maculans.Molecular biology reports · 2024Article
- Antimicrobial potentials of Pandanus amaryllifolius Roxb.: Phytochemical profiling, antioxidant, and molecular docking studies.PloS one · 2024Article
- Microevolution during Chronic Infection May LeadDermatology research and practice · 2024Article
- AflaILVB/G/I and AflaILVD are involved in mycelial production, aflatoxin biosynthesis, and fungal virulence inFrontiers in cellular and infection microbiology · 2024Article
- Molecular Targets of Herbicides and Fungicides─Are There Useful Overlaps for Fungicide Discovery?Journal of agricultural and food chemistry · 2023Review
- Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.Nature communications · 2023Article
- Transcriptomic Profile of Penicillium digitatum Reveals Novel Aspects of the Mode of Action of the Antifungal Protein AfpB.Microbiology spectrum · 2023Article
- Beyond Ergosterol: Strategies for Combatting Antifungal Resistance inTetrahedron · 2023Article
- Drug repurposing strategy II: from approved drugs to agri-fungicide leads.The Journal of antibiotics · 2023Article
- Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study.Antibiotics (Basel, Switzerland) · 2023Article
- Small molecules for combating multidrug-resistant superbugActa pharmaceutica Sinica. B · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased prevalence of drug-resistant human pathogenic fungal diseases poses a major threat to global human health. Thus, new drugs are urgently required to combat these infections. Here, we demonstrate that acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway, is a promising new target for antifungal drug discovery. First, we show that several AHAS inhibitors developed as commercial herbicides are powerful accumulative inhibitors of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.