Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2018
Management of treatment-resistant depression in primary care: a mixed-methods study.
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Experiences of treatment-resistant mental health conditions in primary care: a systematic review and thematic synthesis.BMC primary care · 2022Pooled it
- Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial.Health technology assessment (Winchester, England) · 2025Trial
- Treatment-Related Factors for Medication Non-Adherence Among Patients with Major Depressive Disorder: An Explanatory Sequential Mixed-Methods Study.Patient preference and adherence · 2026Article
- Finding the Prevalence of Autism in Female Mental Illness: Improving Child Development for an Underdiagnosed and Undertreated Population.Children (Basel, Switzerland) · 2025Article
- Care pathways, prescribing practices and treatment outcomes in major depressive disorder and treatment-resistant depression: retrospective, population-based cohort study.BJPsych open · 2024Article
- Predicting quetiapine dose in patients with depression using machine learning techniques based on real-world evidence.Annals of general psychiatry · 2024Article
- Article
- Eliciting Depression Patients' Preferences for Medication Management: A Protocol for Discrete Choice Experiment.Patient preference and adherence · 2024Article
- #TreatmentResistantDepression: A qualitative content analysis of Tweets about difficult-to-treat depression.Health expectations : an international journal of public participation in health care and health policy · 2023Review
- The lived experience of depression: a bottom-up review co-written by experts by experience and academics.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Evaluation, Treatment, and Referral of Treatment-Resistant Depression in Primary Care.The primary care companion for CNS disorders · 2023Article
- Setting national research priorities for difficult-to-treat depression in the UK between 2021-2026.Journal of global health · 2022Article
- Care pathways for people with major depressive disorder: a European Brain Council Value of Treatment study.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- The burden associated with, and management of, difficult-to-treat depression in patients under specialist psychiatric care in the United Kingdom.Journal of psychopharmacology (Oxford, England) · 2022Article
- Predicting Poor Outcomes Among Individuals Seeking Care for Major Depressive Disorder.Psychiatric research and clinical practice · 2022Article
- A retrospective examination of care pathways in individuals with treatment-resistant depression.BJPsych open · 2021Article
- Pharmacological Treatments for Patients with Treatment-Resistant Depression.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Treatment-resistant depression: consider autism.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNon-response to antidepressant medication is common in primary care. Little is known about how GPs manage patients with depression that does not respond to medication.
aimTo describe usual care for primary care patients with treatment-resistant depression (TRD). DESIGN AND
settingMixed-methods study using data from a UK primary care multicentre randomised controlled trial.
methodIn total, 235 patients with TRD randomised to continue with usual GP care were followed up at 3-month intervals for a year. Self-report data were collected on antidepressant medication, number of GP visits, and other treatments received. In addition, 14 semi-structured face-to-face interviews were conducted with a purposive sample after the 6-month follow-up and analysed thematically.
resultsMost patients continued on the same dose of a single antidepressant between baseline and 3 months (
conclusionUsual care in patients with TRD mainly entailed taking antidepressants, and medication changes were uncommon. The high prevalence of physical and psychological comorbidity means that, when these patients consult, their depression may not be discussed. Strategies are needed to ensure the active management of this large group of patients whose depression does not respond to antidepressant medication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.