Evidence map›Paper›PMID 30249596›Full record

ArticleEMBO reports2018

A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export.

Paula Oliete-Calvo, Joan Serrano-Quílez, Carme Nuño-Cabanes, María E Pérez-Martínez, Luis M Soares, Bernhard Dichtl, Stephen Buratowski, José E Pérez-Ortín, Susana Rodríguez-Navarro

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. eIF5A coordinates the transcription and translation of its target genes.Cellular and molecular life sciences : CMLS · 2026
    Article
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Nuclear mRNA export.Acta biochimica et biophysica Sinica · 2024
    Review
  9. Article
  10. Enhanced gene regulation by cooperation between mRNA decay and gene transcription.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023
    Article
  11. Nuclear mRNA Export and Aging.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Paula Oliete-CalvoGene expression and mRNA Metabolism Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain.
Joan Serrano-QuílezGene expression and mRNA Metabolism Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain.ORCID 0000-0002-6578-8463
Carme Nuño-CabanesGene expression and mRNA Metabolism Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain.
María E Pérez-MartínezDepartamento de Bioquímica y Biología Molecular and E.R.I. Biotecmed, Facultad de Biología, Universitat de València, Burjassot, Spain.
Luis M SoaresDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Bernhard DichtlSchool of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Centre for Cellular and Molecular Biology, Deakin University, Geelong, Vic., Australia.
Stephen BuratowskiDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
José E Pérez-OrtínDepartamento de Bioquímica y Biología Molecular and E.R.I. Biotecmed, Facultad de Biología, Universitat de València, Burjassot, Spain.
Susana Rodríguez-NavarroGene expression and mRNA Metabolism Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain srodriguez@ibv.csic.es.ORCID 0000-0001-7472-3111
Consejo Superior de Investigaciones Científicas · ESHarvard University · USUniversitat de València · ESCentro de Investigacion Principe Felipe · ESDeakin University · AU

Funding

The RNA polymerase II transcription complexR01GM046498 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURATOWSKI, STEPHEN · 1996 to 2024
$9.4M
NIGMS NIH HHS R01 GM046498
6 · The paper itself

Abstract

Monoubiquitination of histone H2B (to H2Bub1) is required for downstream events including histone H3 methylation, transcription, and mRNA export. The mechanisms and players regulating these events have not yet been completely delineated. Here, we show that the conserved Ran-binding protein Mog1 is required to sustain normal levels of H2Bub1 and H3K4me3 in

Indexed as

Chromatin ImmunoprecipitationEpigenetic RepressionGene Expression Regulation, FungalHistonesran GTP-Binding ProteinRNA, MessengerRNA Polymerase IIRNA TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTATA-Box Binding ProteinTranscription, GeneticUbiquitinationBre1 protein, S cerevisiaehistone H3 trimethyl Lys4HistonesMOG1 protein, S cerevisiaseran GTP-Binding ProteinRNA, MessengerRNA Polymerase IIRTF1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTATA-Box Binding ProteinepigeneticsH2B ubiquitinationmRNA exporttranscriptionyeast

Identifiers

PMID30249596
PMCPMC6216277
OpenAlexW2890306897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.