ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2018
Comparison of two porcine benign esophageal stricture models using radiofrequency ablation and endoscopic submucosal tunnel dissection.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Paclitaxel-coated balloon catheter for benign esophageal stenosis in a rabbit model.Scientific reports · 2024Article
- A patient-like swine model of gastrointestinal fibrotic strictures for advancing therapeutics.Scientific reports · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
BACKGROUND/
aimsLarge-animal benign esophageal stricture (BES) models are needed for the development of new endoscopic therapies and related devices. This study was undertaken to develop and compare swine BES models produced by radiofrequency ablation (RFA) or endoscopic submucosal tunnel dissection (ESTD). MATERIALS AND
methodsRFA and ESTD were each performed on three pigs. Follow-up endoscopy and esophagography were performed immediately after the procedures and then 2, 3, and 4 weeks later. Four weeks after the procedures, all animals were sacrificed, and gross and histologic examinations were performed.
resultsBES was successfully achieved in both the RFA and ESTD groups, and all animals survived without any serious adverse events during the 4-week follow-up period. Mean procedural times were 9.3 min for RFA and 89.3 min for ESTD. ESTD caused long segment strictures whose average length was 4.5 cm, whereas RFA produced short strictures whose average length was 1.4 cm. BES began to form 2 weeks after both procedures. Degrees of strictures were similar at 3 and 4 weeks in the ESTD group; however, it started deteriorating over time in the RFA group. Histologic examinations showed that ESTD caused inflammation and fibrosis in the submucosal layer, whereas RFA induced extensive inflammation in the submucosal and muscularis propria layers.
conclusionBES was successfully achieved using RFA or ESTD in swine without serious complications. The methods have different characteristics; therefore, researchers should choose the method more appropriate for their purposes.
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