Evidence map›Paper›PMID 30249557›Full record

ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2018

Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk.

Fahri Bilgiç, Emre Gerçeker, Seda Örenay Boyacıoğlu, Elmas Kasap, Ufuk Demirci, Hatice Yıldırım, Ahmed Ramiz Baykan, Hakan Yüceyar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Signaling pathways and therapeutic interventions in gastric cancer.Signal transduction and targeted therapy · 2022
    Review
  3. Review
  4. Review
  5. The roles of ING5 in cancer: A tumor suppressor.Frontiers in cell and developmental biology · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fahri BilgiçDepartment of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey.
Emre GerçekerDepartment of Gastroenterology, Gazi Hospital, İzmir, Turkey.
Seda Örenay BoyacıoğluDepartment of Medical Genetics, Adnan Menderes University School of Medicine, Aydın, Turkey.
Elmas KasapDepartment of Gastroenterology, Celal Bayar University School of Medicine, Manisa, Turkey.
Ufuk DemirciDepartment of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey.
Hatice YıldırımDepartment of Medical Biology, Celal Bayar University School of Medicine, Manisa, Turkey.
Ahmed Ramiz BaykanDepartment of Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Hakan YüceyarDepartment of Gastroenterology, Celal Bayar University School of Medicine, Manisa, Turkey.
Manisa Celal Bayar University · TRAdnan Menderes University · TRErzurum Regional Training and Research Hospital · TRGaziantep Children's Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsAtrophic gastritis (AG), intestinal metaplasia (IM), and Helicobacter pylori (HP) are the risk factors for the development of gastric cancer (GC). Chromatin remodeling is one of the epigenetic mechanisms involved in the carcinogenesis of GC. The purpose of this study was to investigate the expression profiles of defined chromatin remodeling genes in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. MATERIALS AND

methodsIn total, 95 patients were included in the study. Patients were divided into 3 groups as: GC group (n=34), AG group (n=36), and control group (n=25). AG group was further divided into subgroups based on the presence of HP and IM in gastric mucosa. Chromatin remodeling gene expressions were analyzed using real-time PCR (RT-PCR) array in all groups. Data were evaluated using the RT-qPCR primer assay data analysis software.

resultsEED, CBX3, and MTA1 were more overexpressed, whereas ARID1A, ING5, and CBX7 were more underexpressed in the AG and GC groups compared with the controls. No significant differences were observed between the AG and GC groups concerning the expression of these 6 genes, although the fold change levels of these genes in the GC group were well above than in the AG group. EED, CBX3, and MTA1 were significantly more overexpressed in HP- and IM-positive AG subgroup compared with the HP- or IM-negative AG subgroup.

conclusionIn conclusion, our results provide an evidence of epigenetic alterations in AG. Expressions of EED, CBX3, MTA1, ARID1A, ING5, and CBX7 may be considered as promising markers to be used in GC screening for patients with AG.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCase-Control StudiesChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneDNA-Binding ProteinsFemaleGastric MucosaGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHistone DeacetylasesHumansIntestinesMaleARID1A protein, humanBiomarkers, TumorCBX3 protein, humanCBX7 protein, humanChromosomal Proteins, Non-HistoneDNA-Binding ProteinsEED protein, humanHistone DeacetylasesING5 protein, humanMTA1 protein, humanNuclear ProteinsPolycomb Repressive Complex 1Polycomb Repressive Complex 2Repressor ProteinsTrans-ActivatorsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID30249557
PMCPMC6284651
OpenAlexW2891208572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.