ArticleEBioMedicine2018
Increased risk of depression in non-depressed HIV infected men with sleep disturbance: Prospective findings from the Multicenter AIDS Cohort Study.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Pooled it
- Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis.AIDS research and therapy · 2020Pooled it
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Pathogenesis of HIV-associated depression: contributing factors and underlying mechanisms.Frontiers in psychiatry · 2025Review
- Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV.European Medical Journal. Cardiology · 2024Article
- Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Psychosocial Syndemic Classes and Longitudinal Transition Patterns Among Sexual Minority men Living with or Without HIV in the Multicenter AIDS Cohort Study (MACS).AIDS and behavior · 2023Article
- Human Immunodeficiency Virus (HIV) Treatment With Antiretroviral Therapy Mitigates the High Risk of Mental Health Disorders Associated With HIV Infection in the US Population.Open forum infectious diseases · 2023Article
- Combined effects of loneliness and inflammation on depression in people with HIV.Journal of neurovirology · 2023Article
- Profiles of depressive symptoms and influential factors among people living with HIV in China.BMC public health · 2023Article
- NIH Toolbox Emotion Battery Findings Among People with HIV: Normative Comparisons and Clinical Associations.Patient related outcome measures · 2023Article
- Article
- Sleep quality, social rhythms, and depression among people living with HIV: a path analysis based on social zeitgeber theory.Frontiers in psychiatry · 2023Article
- Problems undermining the health-related quality of life of people living with HIV in Spain: a qualitative study to inform the development of a novel clinic screening tool.Health and quality of life outcomes · 2022Review
- Frailty Syndrome Is Associated with Poorer Self-Reported Sleep Quality Among Older Persons with Human Immunodeficiency Virus.AIDS research and human retroviruses · 2022Article
- The relationship between diabetes and depressive symptoms in men with or at risk of HIV infection.HIV medicine · 2021Article
- Article
- Sleep problems in adolescence are prospectively linked to later depressive symptoms via the cortisol awakening response.Development and psychopathology · 2020Article
- Inflammation and Risk of Depression in HIV: Prospective Findings From the Multicenter AIDS Cohort Study.American journal of epidemiology · 2019Article
- Internalized HIV Stigma, Sleep Problems, and Depressive Symptoms in People with HIV in Botswana.Behavioral medicine (Washington, D.C.)Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSleep disturbance is a known risk factor for depression, but it is not known whether sleep disturbance contributes to greater risk of depression in those infected with human immunodeficiency virus (HIV+) as compared to those uninfected with HIV (HIV-).
methodsUsing data from the Multicenter AIDS Cohort Study, a population-based prospective study of men who have sex with men (MSM), self-reported sleep disturbance (>2 weeks) and depressive symptoms (Clinical Epidemiologic Scale for Depression, CES-D) were assessed every 6 months over 12 years of follow-up. Adjusted mixed effects logistic regression analyses tested whether sleep disturbance predicted depression (CES-D ≥ 16) at the immediate subsequent visit, and so on over 12 years, in non-depressed HIV+(N = 1054; 9556 person-visits) and non-depressed HIV- (N = 1217; 12,680 person-visits). In HIV+ vs. HIV- MSM, linearly estimated average incidence of depression and normalized cumulative rate of depression over 12 years were compared.
resultsIn the HIV+ MSM, sleep disturbance was associated with a significant increase in depression 6 months later (OR = 1.6; 95% CI, 1.30, 1.96), which was significantly greater (P < .05) than in HIV- MSM (OR = 1.16; 95% CI, 0.94, 1.44). HIV status and sleep disturbance interacted (P < .001), such that incidence of depression and normalized cumulative rate of depression were greater in HIV+ with sleep disturbance than in HIV+ without sleep disturbance and HIV- groups (all P's < 0.001).
conclusionsHIV+ persons who report sleep disturbance represent a high risk group to be monitored for depression, and possibly targeted for insomnia treatment to prevent depression. FUND: National Institute of Allergy and Infectious Diseases.
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