ArticleMutation research. Genetic toxicology and environmental mutagenesis2018
DNA damaging agents trigger the expression of the HML silent mating type locus in Saccharomyces cerevisiae.
Article in Mutation research. Genetic toxicology and environmental mutagenesis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- A Strategy for the Rapid Development of a SafeInternational journal of molecular sciences · 2021Article
- In Vitro Studies on Therapeutic Potential of Probiotic Yeasts Isolated from Various Sources.Current microbiology · 2020Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Many DNA damaging agents also react with RNA and protein, and could thus cause epigenetic as well as genotoxic changes. To investigate which DNA damaging agents alter epigenetic states, we studied the chemical-induced changes in expression of the yeast silent mating type locus HMLα, which can be triggered by inhibiting yeast Sir2. We observed that the alkylating agent methyl methane sulfonate (MMS) can result in HMLα expression, using a colony sector assay that results from expression of a HML-positioned cre gene. Using single-cell imaging we also observed that alkylating agents, including MMS and methyl-3-nitro-1-nitrosoguanidine (MNNG), as well as short-wave UV, also decreased HML silencing. We suggest that chemical-induced alterations in heterochromatin structure could confer transient phenotypic changes that affect the cellular responses to DNA damaging agents.
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