ReviewJournal of food and drug analysis2018
Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites.
Review in Journal of food and drug analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Omics-enhanced nanomedicine: integrating multi-omics for precision cancer diagnosis and therapy.Discover oncology · 2025Review
- Nanoparticle-assisted strategies in mass spectrometry-based metabolite analysis: recent advances across analytical workflow.Mikrochimica acta · 2025Review
- Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Synthesis of Silver Nanoparticles by Chemical Vapor Deposition Method and Its Application in Laser Desorption/Ionization Techniques.Nanomaterials (Basel, Switzerland) · 2025Review
- Temperature-Driven Morphological and Microstructural Changes of Gold Nanoparticles Prepared by Aggregation from the Gas Phase.ACS omega · 2025Article
- Matrix- and surface-assisted laser desorption/ionization-mass spectrometry analysis of fingermark components for forensic studies: current trends and future prospects.Analytical and bioanalytical chemistry · 2024Review
- Imaging and Non-imaging Analytical Techniques Used for Drug Nanosizing and their Patents: An Overview.Recent patents on nanotechnology · 2024Review
- Organic metal chalcogenide-assisted metabolic molecular diagnosis of central precocious puberty.Chemical science · 2023Article
- Fate of Gold Nanoparticles in Laser Desorption/Ionization Mass Spectrometry: Toward the Imaging of Individual Nanoparticles.Journal of the American Society for Mass Spectrometry · 2023Article
- Surface-assisted laser desorption/ionization mass spectrometry imaging: A review.Mass spectrometry reviews · 2022Review
- Combinatorial Power of cfDNA, CTCs and EVs in Oncology.Diagnostics (Basel, Switzerland) · 2022Review
- Diagnosis and prognosis of breast cancer by high-performance serum metabolic fingerprints.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Laser Ablation Synthesis in Solution and Nebulization of Silver-109 Nanoparticles for Mass Spectrometry and Mass Spectrometry Imaging.ACS measurement science au · 2022Article
- Developing mass spectrometry for the quantitative analysis of neuropeptides.Expert review of proteomics · 2021Review
- A new approach to identifying pathogens, with particular regard to viruses, based on capillary electrophoresis and other analytical techniques.Trends in analytical chemistry : TRAC · 2021Review
- Polydopamine-Modified TS-1 Zeolite Framework Nanoparticles as a Matrix for the Analysis of Small Molecules by MALDI-TOF MS.ACS omega · 2020Article
- Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma.Nature communications · 2020Article
- Article
- Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review.Mikrochimica acta · 2019Article
- Complementarity of Matrix- and Nanostructure-Assisted Laser Desorption/Ionization Approaches.Nanomaterials (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region and high reproducibility. Surface-assisted LDI (SALDI)-MS, especially the nanoparticle-based LDI-MS, has emerged as a promising technique for the analysis of trace amounts of substances in various biological samples due to their high surface area for analyte enrichment, efficient desorption/ionization, and homogeneous crystallization of sample. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields. In this review, we briefly discuss the application of various nanomaterials, which include metal-based, carbon-based, silicon-based nanomaterials and nanocomposites, as matrices and substrates for LDI-MS based drug and metabolite analyses and possible detection strategies. Also, we discuss the idea of using "mass tag" for signal amplification for drug and metabolite detection using nanoparticle assisted LDI-MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.