ArticleFluids and barriers of the CNS2018
Cerebral influx of Na
Article in Fluids and barriers of the CNS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Endovascular intervention and therapeutic plasma exchange in the treatment of cerebral venous thrombosis associated with thyrotoxicosis: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Day-night fluctuations in choroid plexus transcriptomics and cerebrospinal fluid metabolomics.PNAS nexus · 2023Article
- Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production.Fluids and barriers of the CNS · 2023Article
- SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.iScience · 2022Article
- Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.Brain : a journal of neurology · 2022Article
- Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited.Fluids and barriers of the CNS · 2022Review
- CSF Secretion Is Not Altered by NKCC1 Nor TRPV4 Antagonism in Healthy Rats.Brain sciences · 2021Article
- Molecular mechanisms of brain water transport.Nature reviews. Neuroscience · 2021Review
- Resuscitation Strategies for Traumatic Brain Injury.Current surgery reports · 2019Article
- The year in review: progress in brain barriers and brain fluid research in 2018.Fluids and barriers of the CNS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCerebral edema can cause life-threatening increase in intracranial pressure. Besides surgical craniectomy performed in severe cases, osmotherapy may be employed to lower the intracranial pressure by osmotic extraction of cerebral fluid upon intravenous infusion of mannitol or NaCl. A so-called rebound effect can, however, hinder continuous reduction in cerebral fluid by yet unresolved mechanisms.
methodsWe determined the brain water and electrolyte content in healthy rats treated with osmotherapy. Osmotherapy (elevated plasma osmolarity) was mediated by intraperitoneal injection of NaCl or mannitol with inclusion of pharmacological inhibitors of selected ion-transporters present at the capillary lumen or choroidal membranes. Brain barrier integrity was determined by fluorescence detection following intravenous delivery of Na
resultsNaCl was slightly more efficient than mannitol as an osmotic agent. The brain water loss was only ~ 60% of that predicted from ideal osmotic behavior, which could be accounted for by cerebral Na
conclusionsA brain volume regulatory response occurs during osmotherapy, leading to the rebound response. This response involves brain accumulation of Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.